Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo-prolylglycine in rat brain

  • FEBS Lett. 1996 Aug 5;391(1-2):149-52. doi: 10.1016/0014-5793(96)00722-3.
T A Gudasheva  1 ,  S S Boyko ,  V Kh Akparov ,  R U Ostrovskaya ,  S P Skoldinov ,  G G Rozantsev ,  T A Voronina ,  V P Zherdev ,  S B Seredenin
Affiliations
  • 1. Institute of Pharmacology, Russian Academy of Medical Science, Moscow, Russian Federation.
PMID: 8706904 DOI: 10.1016/0014-5793(96)00722-3
Abstract

Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 +/- 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation.

Products