Effect of KW-8232, a novel anti-osteoporotic agent, on bone loss in sciatic neurectomized rats

  • Jpn J Pharmacol. 1998 Oct;78(2):241-3. doi: 10.1254/jjp.78.241.
M Uchii  1 ,  M Takashima ,  T Sugiyama ,  N Kosaka
Affiliations
  • 1. General Pharmacology, Drug Discovery Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
PMID: 9829630 DOI: 10.1254/jjp.78.241
Abstract

The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-+ ++ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.

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