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  2. Drug Isomer
  3. (R)-PAD-PF2

(R)-PAD-PF2 is an isomer of PAD-PF2 (HY-176710). PAD-PF2 is a PAD family inhibitor, as well as a κ-opioid receptor agonist (EC50 = 7.55 μM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 μM).

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(R)-PAD-PF2

(R)-PAD-PF2 Chemical Structure

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Other Forms of (R)-PAD-PF2:

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Description

(R)-PAD-PF2 is an isomer of PAD-PF2 (HY-176710). PAD-PF2 is a PAD family inhibitor, as well as a κ-opioid receptor agonist (EC50 = 7.55 μM) and an M1 muscarinic acetylcholine receptor antagonist (IC50 = 12.3 μM).

Molecular Weight

484.42

Formula

C25H27Cl2N5O

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCCC1)[C@H](N)C2CCN(C3=NC=CC4=C3C=CC=C4C5=NC=C(Cl)C=C5Cl)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0643 mL 10.3216 mL 20.6432 mL
5 mM 0.4129 mL 2.0643 mL 4.1286 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0643 mL 10.3216 mL 20.6432 mL 51.6081 mL
5 mM 0.4129 mL 2.0643 mL 4.1286 mL 10.3216 mL
10 mM 0.2064 mL 1.0322 mL 2.0643 mL 5.1608 mL
15 mM 0.1376 mL 0.6881 mL 1.3762 mL 3.4405 mL
20 mM 0.1032 mL 0.5161 mL 1.0322 mL 2.5804 mL
25 mM 0.0826 mL 0.4129 mL 0.8257 mL 2.0643 mL
30 mM 0.0688 mL 0.3441 mL 0.6881 mL 1.7203 mL
40 mM 0.0516 mL 0.2580 mL 0.5161 mL 1.2902 mL
50 mM 0.0413 mL 0.2064 mL 0.4129 mL 1.0322 mL
60 mM 0.0344 mL 0.1720 mL 0.3441 mL 0.8601 mL
80 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6451 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5161 mL
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(R)-PAD-PF2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(R)-PAD-PF2
Cat. No.:
HY-176710A
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