2. Metabolic Enzyme/Protease
  3. Oxidative Phosphorylation
  4. R419

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer.

For research use only. We do not sell to patients.

R419

R419 Chemical Structure

CAS No. : 1356629-00-9

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Description

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
19.5 μM
Compound: R419
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 30001917]
A549 IC50
> 20 μM
Compound: 40
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay
[PMID: 35973281]
C2C12 EC50
0.23 μM
Compound: 2, R419
Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs
Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs
[PMID: 25122135]
HepG2 EC50
0.03 μM
Compound: 2, R419
Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs
Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs
[PMID: 25122135]
HepG2 IC50
2.817 μM
Compound: 4; R419
Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production
Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production
[PMID: 38079537]
HepG2 IC50
5.2 μM
Compound: R419
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 30001917]
L02 IC50
25.9 μM
Compound: R419
Cytotoxicity against human L02 cells after 72 hrs by MTT assay
Cytotoxicity against human L02 cells after 72 hrs by MTT assay
[PMID: 30001917]
NCI-H1299 IC50
> 20 μM
Compound: 40
Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay
Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay
[PMID: 35973281]
Molecular Weight

565.66

Formula

C33H35N5O4
CAS No.
SMILES

N#CC1=CC=C(CN2CCC(CC2)NC(C3=CN=C(C(N4CCC(CC4)C(C5=CC=C(C=C5)OC)=O)=O)C=C3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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R419 Related Classifications

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The molarity calculator equation

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Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

R4191356629-00-9R 419R-419Oxidative PhosphorylationHepG2anti-cancerInhibitorinhibitorinhibit

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