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Cat. No.: HY-153156

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R419

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer.

For research use only. We do not sell to patients.

CAS No.: 1356629-00-9
Formula: C₃₃H₃₅N₅O₄
Molecular Weight:565.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

R419 Chemical Structure

CAS No.: 1356629-00-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]
A549	IC₅₀	19.5 μM Compound: R419	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30001917]
C2C12	EC₅₀	0.23 μM Compound: 2, R419	Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	EC₅₀	0.03 μM Compound: 2, R419	Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	IC₅₀	2.817 μM Compound: 4; R419	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
HepG2	IC₅₀	5.2 μM Compound: R419	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30001917]
L02	IC₅₀	25.9 μM Compound: R419	Cytotoxicity against human L02 cells after 72 hrs by MTT assay Cytotoxicity against human L02 cells after 72 hrs by MTT assay	[PMID: 30001917]
NCI-H1299	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]

Chemical Information

CAS No. 1356629-00-9
Molecular Weight 565.66
Formula C₃₃H₃₅N₅O₄
SMILES

N#CC1=CC=C(CN2CCC(CC2)NC(C3=CN=C(C(N4CCC(CC4)C(C5=CC=C(C=C5)OC)=O)=O)C=C3)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2957-2960. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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