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Cat. No.: HY-153156

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R419

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1356629-00-9
화학식: C₃₃H₃₅N₅O₄
분자량:565.66

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

R419 Chemical Structure

CAS No.: 1356629-00-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

R419 is a Complex I inhibitor. R419 has anti-cancer activity against liver cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]
A549	IC₅₀	19.5 μM Compound: R419	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 30001917]
C2C12	EC₅₀	0.23 μM Compound: 2, R419	Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs Activation of AMPK in human C2C12 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	EC₅₀	0.03 μM Compound: 2, R419	Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs Activation of AMPK in human HepG2 cells using ACC as substrate after 2 hrs	[PMID: 25122135]
HepG2	IC₅₀	2.817 μM Compound: 4; R419	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
HepG2	IC₅₀	5.2 μM Compound: R419	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30001917]
L02	IC₅₀	25.9 μM Compound: R419	Cytotoxicity against human L02 cells after 72 hrs by MTT assay Cytotoxicity against human L02 cells after 72 hrs by MTT assay	[PMID: 30001917]
NCI-H1299	IC₅₀	>20 μM Compound: 40	Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay Antiproliferative activity against human NCI-H1299 cells assessed as cell growth inhibition incubated for 48 hrs by DAPI staining assay	[PMID: 35973281]

Chemical Information

CAS No. 1356629-00-9
분자량 565.66
화학식 C₃₃H₃₅N₅O₄
SMILES

N#CC1=CC=C(CN2CCC(CC2)NC(C3=CN=C(C(N4CCC(CC4)C(C5=CC=C(C=C5)OC)=O)=O)C=C3)=O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2957-2960. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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