(±)-Salsolinol hydrochloride
Based on 1 Customer Validation
(±)-Salsolinol hydrochloride is the hydrochloride form of (±)-Salsolinol (HY-113316). (±)-Salsolinol hydrochloride is a Dopamine (HY-B0451)-derived endogenous metabolite. (±)-Salsolinol hydrochloride activates μ-opioid receptors (MORs), reduces GABAergic transmission, increases the excitability of dopamine (DA) neurons, and thus accelerates the sustained firing of neurons in the posterior ventral tegmental area (pVTA).
For research use only. We do not sell to patients.
- Purity: 98.55%
- CAS No.: 79923-51-6
- Formula: C10H14ClNO2
- Molecular Weight:215.68
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
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Bioactive Compound Library
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GPCR/G Protein Compound Library
HY-L006
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Metabolism/Protease Compound Library
HY-L012
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Neuronal Signaling Compound Library
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Human Endogenous Metabolite Compound Library
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Neurotransmitter Receptor Compound Library
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Traditional Chinese Medicine Active Compound Library
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Food-Sourced Compound Library
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Antidepressant Compound Library
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Human Metabolite Library
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Pain-Related Compound Library
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Membrane Protein-targeted Compound Library
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Membrane Receptor-targeted Compound Library
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Animal-Sourced Natural Product Library
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Highly Selective Activators Library
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Protein Kinase Compound Library
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RO5 Drug-like Natural Product Library
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High-Throughput Bioactive Compound Library
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Mass Spectrometry Human Endogenous Metabolite Library
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Mass Spectrometry Human Metabolite Library
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Natural Product Diversity Scaffold Library
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Lactylation Compound Library
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Biological Activity
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Human Endogenous Metabolite |
Chemical Information
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CAS No. 79923-51-6
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Appearance Solid
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Molecular Weight 215.68
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Formula C10H14ClNO2
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Color White to off-white
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SMILES
OC1=CC2=C(C(C)NCC2)C=C1O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (231.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6365 mL | 23.1825 mL | 46.3650 mL | 115.9125 mL |
| 5 mM | 0.9273 mL | 4.6365 mL | 9.2730 mL | 23.1825 mL | |
| 10 mM | 0.4636 mL | 2.3182 mL | 4.6365 mL | 11.5912 mL | |
| 15 mM | 0.3091 mL | 1.5455 mL | 3.0910 mL | 7.7275 mL | |
| 20 mM | 0.2318 mL | 1.1591 mL | 2.3182 mL | 5.7956 mL | |
| 25 mM | 0.1855 mL | 0.9273 mL | 1.8546 mL | 4.6365 mL | |
| 30 mM | 0.1545 mL | 0.7727 mL | 1.5455 mL | 3.8637 mL | |
| 40 mM | 0.1159 mL | 0.5796 mL | 1.1591 mL | 2.8978 mL | |
| 50 mM | 0.0927 mL | 0.4636 mL | 0.9273 mL | 2.3182 mL | |
| 60 mM | 0.0773 mL | 0.3864 mL | 0.7727 mL | 1.9319 mL | |
| 80 mM | 0.0580 mL | 0.2898 mL | 0.5796 mL | 1.4489 mL | |
| 100 mM | 0.0464 mL | 0.2318 mL | 0.4636 mL | 1.1591 mL |
(±)-Salsolinol hydrochloride Related Classifications
HY-113316A Related Classifications
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