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RH01386 

Cat. No.: HY-124771
Handling Instructions

RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment.

For research use only. We do not sell to patients.

RH01386 Chemical Structure

RH01386 Chemical Structure

CAS No. : 301177-36-6

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Description

RH01386 is a small molecule that can prevent ER stress-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ER stress-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1].

IC50 & Target

ER stress-induced β cell dysfunction[1]

In Vitro

RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1].
RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1].

Cell Viability Assay[1]

Cell Line: βTC6 cells
Concentration: 270 nM-70 μM
Incubation Time: 72 hours
Result: Inhibited ER stress-induced death of βTC6 cells in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: βTC6 cells
Concentration: 270 nM-70 μM
Incubation Time: 72 hours
Result: Protected βTC6 cells from Tm-induced cell death.
Molecular Weight

424.40

Formula

C₁₈H₁₅F₃N₄O₃S

CAS No.

301177-36-6

SMILES

N#CC1=C(C2CCCCC2)N=C(SC3=CC=C(C(F)(F)F)C=C3[N+]([O-])=O)NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RH01386RH 01386RH-01386Othersβ cell type 2 diabetes βTC6 cellsInhibitorinhibitorinhibit

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RH01386
Cat. No.:
HY-124771
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