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Cat. No.: HY-183052

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RIPK3-IN-7

RIPK3-IN-7 is a RIPK3 inhibitor that suppresses the RIPK3-mediated necroptosis pathway. RIPK3-IN-7 can be used for research on necroptosis and inflammation-related diseases.

For research use only. We do not sell to patients.

CAS No.: 3116772-57-4
Formula: C₂₄H₂₅N₃O₂S₂
Molecular Weight:451.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RIPK3-IN-7 Chemical Structure

CAS No.: 3116772-57-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Help & FAQs
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Biological Activity

Description

RIPK3-IN-7 is a RIPK3 inhibitor that suppresses the RIPK3-mediated necroptosis pathway. RIPK3-IN-7 can be used for research on necroptosis and inflammation-related diseases^[1].

All RIP kinase Isoforms :

In Vitro

RIPK3-IN-7 (LK-18) (20 μM) inhibits RIPK3-mediated necrosis in L929 cells and HT29 cells, with an EC₅₀ of 1.2 μM, has a high selectivity ratio (CC₅₀/EC₅₀) of 44.3, and does not induce Caspase-3 activation at 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3116772-57-4
Molecular Weight 451.60
Formula C₂₄H₂₅N₃O₂S₂
SMILES

O=S(=O)(C=1C=CC2=NC=CC(NC=3C=CC=4SC(=NC4C3)C5CCCC5)=C2C1)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu YC, et al. 2-Substituted azole cell necrosis pathway inhibitor and preparation method and application thereof. CN121471209A. 2025-08-05.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
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Purity & Documentation
References

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RIPK3-IN-7

All RIP kinase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

RIPK3-IN-7 Related Classifications

HY-183052 Related Classifications