2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. RM1490

RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC50 ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC50 > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.

For research use only. We do not sell to patients.

RM1490

RM1490 Chemical Structure

CAS No. : 2849392-47-6

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RM1490 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC50 ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC50 > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

≤ 300 nM (IC50)

δ Opioid Receptor/DOR

> 3000 nM (EC50)

κ Opioid Receptor/KOR

≤ 300 nM (IC50)

In Vitro

RM1490 (Compound 251) (Serially diluted concentrations; 15 minutes at 37°C, 5% CO2 plus 15 minutes at room temperature) potently antagonizes the mu opioid receptor in CHO Tag-lite human mOR stable cells with an IC50 ≤ 300 nM[1].
RM1490 (Compound 251) acts as a weak agonist of the delta opioid receptor with an EC50 > 3000 nM[1].
RM1490 (Compound 251) potently antagonizes kappa opioid receptor β-arrestin signaling with an IC50 ≤ 300 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RM1490 Related Antibodies
Molecular Weight

394.55

Formula

C25H34N2O2
CAS No.
SMILES

CC(C=C(C=C1C)O)=C1C[C@H](N(C)C)CNC(C[C@H](C2=CC=CC=C2)C3CC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RM1490 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RM14902849392-47-6RM 1490RM-1490Opioid Receptorkappa opioid receptoralcohol addictionobsessive compulsive disordercAMP signalinggambling addictionβ-arrestin activityneuropsychiatric disordersdepressionmu opioid receptordelta opioid receptorInhibitorinhibitorinhibit

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