RM1490
RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor (MOR) (IC50 ≤ 300 nM), an activator of δ-opioid receptor (DOR) (EC50 > 3000 nM), and an inhibitor of κ-opioid receptor (KOR) (IC50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.
For research use only. We do not sell to patients.
- CAS No.: 2849392-47-6
- Formula: C25H34N2O2
- Molecular Weight:394.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Opioid Receptor Isoforms
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Biological Activity
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μ Opioid Receptor/MOR ≤ 300 nM (IC50) |
δ Opioid Receptor/DOR > 3000 nM (EC50) |
κ Opioid Receptor/KOR ≤ 300 nM (IC50) |
RM1490 (Compound 251) (Serially diluted concentrations; 15 minutes at 37°C, 5% CO2 plus 15 minutes at room temperature) potently antagonizes the mu opioid receptor in CHO Tag-lite human mOR stable cells with an IC50 ≤ 300 nM[1].
RM1490 (Compound 251) acts as a weak agonist of the delta opioid receptor with an EC50 > 3000 nM[1].
RM1490 (Compound 251) potently antagonizes kappa opioid receptor β-arrestin signaling with an IC50 ≤ 300 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2849392-47-6
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Molecular Weight 394.55
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Formula C25H34N2O2
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SMILES
CC(C=C(C=C1C)O)=C1C[C@H](N(C)C)CNC(C[C@H](C2=CC=CC=C2)C3CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RM1490 Related Classifications
HY-182453 Related Classifications
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