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Cat. No.: HY-190470

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RORγ inverse agonist-3

RORγ inverse agonist-3 is a RORγ inverse agonist. RORγ inverse agonist-3 also reduces RORα- and RORβ-dependent transcriptional reporter activity.

For research use only. We do not sell to patients.

CAS No.: 2609873-16-5
Formula: C₂₈H₄₄O₃
Molecular Weight:428.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

RORγ inverse agonist-3 Chemical Structure

CAS No.: 2609873-16-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

RORγ inverse agonist-3 is a RORγ inverse agonist. RORγ inverse agonist-3 also reduces RORα- and RORβ-dependent transcriptional reporter activity^[1].

IC₅₀ & Target

^[1]

RORγ

6.1 μM (IC₅₀)

RORα

8.5 μM (IC₅₀)

RORβ

11.6 μM (IC₅₀)

All ROR Isoforms :

In Vitro

RORγ inverse agonist-3 (Compound 14) (10 μM) is a low-micromolar ROR inverse agonist with broad-spectrum activity against RORα/β/γ and moderate preference for RORγ (RORγ IC₅₀ = 6.1 μM) (IC₅₀ values determined by Gal4 hybrid reporter gene assay)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2609873-16-5
Molecular Weight 428.65
Formula C₂₈H₄₄O₃
SMILES

C[C@@]12[C@@]3([C@H](OC)C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@@H]([C@@H]6[C@@H](C(OCC)=O)C6)C)C[C@H]3CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shanmugamani S, et al. Demethylgorgosterol-derived steroids as a new class of RORγ-preferential inverse agonists. European journal of medicinal chemistry. 2026 Oct 08;321(Pt 2):119391.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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