2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. RS100329 hydrochloride

RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia.

For research use only. We do not sell to patients.

RS100329 hydrochloride Chemical Structure

RS100329 hydrochloride Chemical Structure

CAS No. : 1215654-26-4

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Based on 1 publication(s) in Google Scholar

RS100329 hydrochloride Related Antibodies

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Description

RS100329 hydrochloride is a potent and selective α1A-adrenoceptor antagonist with pKi values of 9.6, 7.9 and 7.5 for α1A, α1D, and α1B, respectively. RS100329 hydrochloride inhibits reflex urethral contractions. RS100329 hydrochloride can be used in research of benign prostatic hyperplasia[1][2].

IC50 & Target

pKi: 9.6 (α1A-adrenoceptor), 7.9 (α1D-adrenoceptor) and 7.5 (α1B-adrenoceptor)[2]
In Vitro

RS100329 hydrochloride (human lower urinary tract (LUT) tissues) contractions to Norepinephrine (HY-13715) is antagonized in a surmountable and concentration-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RS100329 hydrochloride Related Antibodies
In Vivo

RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.; Sprague Dawley rats) reduces baseline urethral pressure and inhibit reflex urethral contractions[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats (300-390 g)[1]
Dosage: 0.01-0.1 mg/kg
Administration: Intravenous injection
Result: Caused a fall in baseline urethral pressure reaching a maximum of 23%.
Molecular Weight

462.89

Formula

C20H26ClF3N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2)C(C(C)=CN1)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (67.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1603 mL 10.8017 mL 21.6034 mL
5 mM 0.4321 mL 2.1603 mL 4.3207 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1603 mL 10.8017 mL 21.6034 mL 54.0085 mL
5 mM 0.4321 mL 2.1603 mL 4.3207 mL 10.8017 mL
10 mM 0.2160 mL 1.0802 mL 2.1603 mL 5.4009 mL
15 mM 0.1440 mL 0.7201 mL 1.4402 mL 3.6006 mL
20 mM 0.1080 mL 0.5401 mL 1.0802 mL 2.7004 mL
25 mM 0.0864 mL 0.4321 mL 0.8641 mL 2.1603 mL
30 mM 0.0720 mL 0.3601 mL 0.7201 mL 1.8003 mL
40 mM 0.0540 mL 0.2700 mL 0.5401 mL 1.3502 mL
50 mM 0.0432 mL 0.2160 mL 0.4321 mL 1.0802 mL
60 mM 0.0360 mL 0.1800 mL 0.3601 mL 0.9001 mL
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RS100329 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS1003291215654-26-4RS 100329RS-100329Adrenergic ReceptorBeta Receptorhuman lower urinary tractbenign prostatic hyperplasiaurethral contractionsbaseline urethral pressureInhibitorinhibitorinhibit

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