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Cat. No.: HY-187922

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Rufutalkib

Rufutalkib is an orally active ALK modulator. It possesses thermodynamic and chemical stability, and can be used in research related to anaplastic large cell lymphoma, non-Hodgkin's lymphoma, inflammatory myofibroblastic tumor, neuroblastoma, glioblastoma, and ALK-positive malignancies.

For research use only. We do not sell to patients.

CAS No.: 1609170-61-7
Formula: C₂₉H₃₆ClN₅O₃S
Molecular Weight:570.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rufutalkib Chemical Structure

CAS No.: 1609170-61-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Rufutalkib succinate Form VI is hygroscopic with a 5.4% weight gain at 80% RH, and converts to an amorphous state after moisture sorption testing^[1].
Rufutalkib succinate Form VI has high solubility in simulated gastric fluid (7.34-7.35 mg/mL) and low solubility in fasted-state simulated intestinal fluid (0.10 mg/mL) over a 4-hour period at 37°C^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-t	T_1/2	Bioavailability
Rat^[1]	1 mg/kg	i.g.	3 h	168 ng/mL	2810 ng·h/mL	7.55 h	69.0 %
Rat^[1]	2 mg/kg	i.g.	4 h	322 ng/mL	6164 ng·h/mL	8.39 h	/
Rat^[1]	4 mg/kg	i.g.	4 h	451 ng/mL	10043 ng·h/mL	8.31 h	/
Rat^[1]	1 mg/kg	i.v.	/	/	4071 ng·h/mL	7.23 h	/

In Vivo

Rufutalkib (1-4 mg/kg; i.v., i.g.; single dose) demonstrates high oral bioavailability of approximately 69.0% in rats, with dose-dependent exposure following single i.g. administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1609170-61-7
Molecular Weight 570.15
Formula C₂₉H₃₆ClN₅O₃S
SMILES

CC1=CC(NC2=NC=C(Cl)C(NC3=C(C=CC=C3)S(C(C)C)(=O)=O)=N2)=C4C(C[C@H](O4)C)=C1C5CCN(CC5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang K Y, et al. Crystal form of alk inhibitor. WO2025040026A1. World Intellectual Property Organization. 2025-02-27.

[2]. Wang W, et al. Certain protein kinase inhibitors. US20140128387A1. United States Patent and Trademark Office. 2014-05-08.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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