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Cat. No.: HY-108019

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SD 8381

SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC₅₀ values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1.

For research use only. We do not sell to patients.

CAS No.: 215123-80-1
Formula: C₁₁H₅Cl₂F₃O₃
Molecular Weight:313.06

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SD 8381 Chemical Structure

CAS No.: 215123-80-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC₅₀ values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1^[1].

IC₅₀ & Target^[1]

hCOX-1

0.69 μM (IC₅₀)

hCOX-2

0.0098 μM (IC₅₀)

All COX Isoforms :

Chemical Information

CAS No. 215123-80-1
Molecular Weight 313.06
Formula C₁₁H₅Cl₂F₃O₃
SMILES

ClC1=C2C(C=C([C@H](O2)C(F)(F)F)C(O)=O)=CC(Cl)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang JL, et al. The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: the first clinical candidate. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7155-8. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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SD 8381

All COX Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

SD 8381 Related Classifications

HY-108019 Related Classifications