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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
323 Results for "
linear
" in MedChemExpress (MCE) Product Catalog:
Products (323)
323 Results for "linear" in MCE Product Catalog:
23
Category:
Polysaccharides Neurological Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology Saccharides
Target:
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Target:
Forschungsgebiete:
Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer .
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5 Cited Publications
Synonyms: Deacetylated chitin (MW 150000) (≥85% deacetylated); Poly(D-glucosamine) (MW 150000) (≥85% deacetylated)
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Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
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5 Cited Publications
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HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC .
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HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM . HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro .
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2 Cited Publications
Art. -Nr.: HY-P1539
CAS. Nr.: 80451-04-3
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2
2 Cited Publications
Art. -Nr.: HY-N12304
CAS. Nr.: 21800-48-6
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2 Cited Publications
Synonyms: Deacetylated chitin (MW 30000) (≥85% deacetylated); Poly(D-glucosamine) (MW 30000) (≥85% deacetylated)
Target:
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
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2 Cited Publications
Art. -Nr.: HY-N6708
CAS. Nr.: 27061-78-5
Category:
Infection Microorganisms Antibiotics Mammalian Cell Culture Disease Research Antibacterial Disease Research Fields Other Antibiotics
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1 Cited Publications
Art. -Nr.: HY-W1048553B
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1 Cited Publications
Art. -Nr.: HY-D1668
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1 Cited Publications
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Forschungsgebiete:
PROTAC MLKL Degrader-1 is a selective MLKL PROTAC degrader with a DC50 of 2.4 μM. PROTAC MLKL Degrader-1 blocks necroptosis without modulating the phosphorylation of RIPK1 or RIPK3, and exhibits a linear correlation between MLKL levels and necroptotic cell death .
1
1 Cited Publications
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery .
1
1 Cited Publications
Synonyms: L-Ureidosuccinic acid
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
