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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
255 Results for "
human KB
" in MedChemExpress (MCE) Product Catalog:
Products (255)
255 Results for "human KB" in MCE Product Catalog:
Cat. No.: HY-P5523
CAS No.: 592520-07-5
Research Areas:
Cat. No.: HY-P5523A
Research Areas:
Cat. No.: HY-W050154S
Cat. No.: HY-15616
CAS No.: 457893-92-4
Target:
Research Areas:
BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation .
Cat. No.: HY-174829
CAS No.: 13198-99-7
Target:
Protease Activated Receptor (PAR) NF-κB Reactive Oxygen Species (ROS) Calcium Channel Akt ERK p38 MAPK PKC
Research Areas:
7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, Ca 2+/protein kinase C, Akt, ERK and p38. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice.
7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time [1][2].
Cat. No.: HY-P99911
CAS No.: 1635395-27-5
Synonyms: MEDI-6383
Target:
Research Areas:
Synonyms: Potassium phosphate monobasic, meets analytical specification of Ph. Eur., NF, E340
Cat. No.: HY-P705400
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: H-2 class I histocompatibility antigen, K-B alpha chain; H-2K(B); H2-K1; H2-K; B2M; Beta 2-Microglobulin; Beta-2-Microglobulin; Beta-2-Microglobin; Beta Chain Of MHC Class I Molecules; AMYLD6; Beta 2-Microglobulin Protein; MHC1D4; human Nkt Tcr Alpha Chain; IMD43; human Nkt Tcr Beta Chain
Species:
Mouse
Source:
HEK293
Target:
Research Areas:
2'-Hydroxy-4-methoxychalcone is a PPARγ agonist. 2'-Hydroxy-4-methoxychalcone also exhibits inhibitory activity against gelatinase/collagenase and human glutathione S-transferase (GST), with an IC50 of 5.2 μM and a Ki of 15.36 μM against GST. 2'-Hydroxy-4-methoxychalcone inhibits both the NF-κB and AP-1 signaling pathways, exerting anti-inflammatory activity; it also inhibits COX-2, conferring anti-cancer/anti-angiogenic activity. 2'-Hydroxy-4-methoxychalcone can be used in studies related to atherosclerosis, inflammatory diseases and cancer .
Target:
Cat. No.: HY-N3225
CAS No.: 33606-81-4
Cat. No.: HY-P5524
CAS No.: 1269619-57-9
Synonyms: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid; γ-D-glutamyl-meso-diaminopimelic acid
Research Areas:
Cat. No.: HY-P992395
Synonyms: JNJ-711
Target:
Research Areas:
Cat. No.: HY-P706097
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: RPS6KB1; Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1; Prev. STK14A; 70 KDa Ribosomal Protein S6 Kinase 1; S6K1; Serine/Threonine Kinase 14 Alpha; P70(S6K)-Alpha; P70 Ribosomal S6 Kinase Alpha; PS6K; P70 S6 Kinase Alpha; S6K; RPS6KB1 Protein; Serine/Threonine-Protein Kinase 14A; P70 S6K-Alpha; Ribosomal Protein S6 Kinase Beta-1; P70-Alpha; Ribosomal Protein S6 Kinase I; P70-S6K 1; S6K-Beta-1; P70-S6K; P70 S6KA; P70S6K1; Ribosomal Protein S6 Kinase B1; Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71399
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2D1; Ubiquitin Conjugating Enzyme E2 D1; SFT; UBCH5; Stimulator Of Fe Transport; E2(17)KB1; UbcH5A; UBC4/5; Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog,Yeast); (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D1; Ubiquitin-Conjugating Enzyme E2-
Species:
Human
Source:
E. coli
Cat. No.: HY-P85906
Synonyms: CK 4; CK-4; CK4; CYK4; Cytokeratin 4; CytokeRatin-4; CytokeRatin4; FLJ31692; K2C4_human; K4; KeRatin 4; KeRatin; KeRatin type II cytoskeletal 4; KeRatin-4; KeRatin4; KRT 4; Krt4; type II cytoskeletal 4; Type-II keRatin KB4
Cat. No.: HY-P991510
Target:
Research Areas:
Cat. No.: HY-107574R
CAS No.: 17328-16-4
Research Areas:
TC-E 5003 (Standard) is the analytical standard of TC-E 5003 (HY-107574). This product is intended for research and analytical applications. TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein Kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers .
Cat. No.: HY-123925
CAS No.: 2244988-80-3
Target:
Research Areas:
CSLP43 is a selective RIPK2 and XIAP inhibitor with an IC50 of 19.9 nM against human RIPK2. CSLP43 binds to the ATP-binding pocket of RIPK2 and disrupts the interaction between RIPK2 and the BIR2 domain of XIAP or cIAP1. CSLP43 inhibits RIPK2 ubiquitination, NOD1-dependent inflammatory signaling pathways, NOD2-dependent inflammatory signaling pathways, as well as NF-κB activation associated with NOD agonists. CSLP43 is selective for the NOD1/NOD2 signaling pathway and does not inhibit the kinase activity of RIPK1 or RIPK3. CSLP43 is applicable to research related to Crohn's disease, Blau syndrome, early-onset sarcoidosis and early-onset inflammatory bowel disease .
Cat. No.: HY-171895
CAS No.: 774603-05-3
Synonyms: 12-Nitro-9-cis,12-cis-octadecadienoic acid
Target:
Research Areas:
12-Nitrolinoleate (12-Nitro-9-cis,12-cis-octadecadienoic acid) is an activator for peroxisome proliferator-activated receptor γ (PPARγ). 12-Nitrolinoleate is a nitrated form of linoleic acid. 12-Nitrolinoleate can be formed upon exposure to acidified nitrate and found in human red blood cells and plasma. 12-Nitrolinoleate can activate PPARγ-dependent gene expression in MCF-7 cells expressing PPARγ with an EC50 = 0.045 μM. 12-Nitrolinoleate is able to inhibit LPS (HY-D1056)-induced NF-κB transcription in RAW 264.7 cells. 12-Nitrolinoleate can inhibit IL-6, TNF-α and CCL2 induced by LPS .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
