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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
255 Results for "
human KB
" in MedChemExpress (MCE) Product Catalog:
Products (255)
255 Results for "human KB" in MCE Product Catalog:
Synonyms: Potassium phosphate monobasic (Pharmaceutical primary standard, USP)
Cat. No.: HY-P705524
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FOLR1; KB Cells FBP; Prev. FOLR; FBP; Ovarian Tumor-Associated Antigen MOv18; Folate Binding Protein; Adult Folate-Binding Protein; FRalpha; Folate Receptor 1 (Adult); NCFTD; Folate Receptor, Adult; FRα; Folate Receptor 1; FRA; Folate Receptor Alpha; FR-A
Species:
Human
Source:
HEK293
Cat. No.: HY-118973
CAS No.: 1807810-16-7
Research Areas:
LASSBio-1829 hydrochloride is an orally active IKK2 inhibitor with an IC50 of 3.8 μM against the human target (Sf21 cells). LASSBio-1829 hydrochloride blocks signal transduction of the inflammation-associated NF-κB activation pathway. LASSBio-1829 hydrochloride reduces leukocyte migration, TNF-α biosynthesis, ROS production and NO production. LASSBio-1829 hydrochloride exhibits anti-inflammatory activity in a carrageenan-induced subcutaneous air pouch mouse model. LASSBio-1829 hydrochloride alleviates licking behavior during the inflammatory phase of the mouse formalin test. LASSBio-1829 hydrochloride can be used in inflammation-related research .
Cat. No.: HY-122308R
CAS No.: 58139-23-4
Target:
Cat. No.: HY-161627
CAS No.: 2919975-48-5
Research Areas:
Anemoside A3-methyl 6-aminohexanoate is an orally effective pyruvate carboxylase (PC) inhibitor with a Kd value of 10.1 μM against human PC. Anemoside A3-methyl 6-aminohexanoate exerts its function through the PC/NF-κB/NLRP3 inflammasome axis. Anemoside A3-methyl 6-aminohexanoate significantly alleviates symptoms of DSS (HY-116282C)-induced colitis in mice. Anemoside A3-methyl 6-aminohexanoate can be used in colitis-related research .
Cat. No.: HY-162805
Target:
Research Areas:
iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM) .
Cat. No.: HY-164374
CAS No.: 445007-59-0
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .
Cat. No.: HY-210247
CAS No.: 3066447-73-9
Research Areas:
RIPK2-IN-9 is a RIPK2 inhibitor with an IC50 < 2.5 nM. RIPK2-IN-9 inhibits NOD2-mediated NF-κB signaling and the protein-protein interaction between RIPK2 and XIAP, and inhibits NOD2 ligand-induced TNF-α secretion in human whole blood. RIPK2-IN-9 exhibits low inhibitory activity against the hERG channel. RIPK2-IN-9 can be used for research on RIPK2-related inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis .
Target:
Category:
Cardiovascular Disease Alkaloids Plants Other Families Extract Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology
Target:
Cat. No.: HY-N9454
CAS No.: 91893-83-3
Cat. No.: HY-N0515R
CAS No.: 945619-74-9
Cat. No.: HY-P705570
Synonyms: RPS6KB1; Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1; Prev. STK14A; 70 KDa Ribosomal Protein S6 Kinase 1; S6K1; Serine/Threonine Kinase 14 Alpha; P70(S6K)-Alpha; P70 Ribosomal S6 Kinase Alpha; PS6K; P70 S6 Kinase Alpha; S6K; RPS6KB1 Protein; Serine/Threonine-Protein Kinase 14A; P70 S6K-Alpha; Ribosomal Protein S6 Kinase Beta-1; P70-Alpha; Ribosomal Protein S6 Kinase I; P70-S6K 1; S6K-Beta-1; P70-S6K; P70 S6KA; P70S6K1; Ribosomal Protein S6 Kinase B1; Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-126914
CAS No.: 62574-06-5
Diacetylcercosporin is a perylenequinone produced by Cercospora and Septoria that has diverse biological activities. Diacetylcercosporin inhibits the growth of P. falciparum strains that are sensitive and resistant to chloroquine (IC50s=2.75 and 1.94 μM for D6 and W2 clones, respectively) and L. donovani parasites (IC50=3.1 μM) in vitro. Diacetylcercosporin exhibits cytotoxicity against SK-MEL, KB, BT549, and SKOV3 human cancer cell lines (IC50s=4.8-8.7 μM). Diacetylcercosporin is also a phytotoxin that inhibits the growth of lettuce and bentgrass at a concentration of 1.62 mM.
Cat. No.: HY-N6861
CAS No.: 95311-95-8
Category:
Cardiovascular Disease Cercis chinensis Bunge Metabolic Disease Plants Other Families Extract Flavonoids Flavonones Phenols Polyphenols Compositae Extract Disease Research Fields
Target:
Cat. No.: HY-183105
CAS No.: 2133291-32-2
Target:
Research Areas:
DC551040 is an orally active and selective lysine demethylase 1 (LSD1) inhibitor with a human IC50 of 2.14 nM. DC551040 binds to LSD1 via π-π stacking with Trp552, polar interactions with Phe538, and covalent adduct formation with FAD, and disrupts the LSD1-GFI1B-CoREST complex. DC551040 induces H3K4me2 accumulation, apoptosis, and cell differentiation, activates STAT5, NF-κB, AKT, and IL6-STAT3 pathways, and upregulates IL6 expression. DC551040 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-187220
CAS No.: 3119216-05-3
Target:
Research Areas:
β5i-IN-2 is a potent, selective, and orally active inhibitor of the immunoproteasome β5i subunit, with an IC50 of 0.08 μM against human β5i. β5i-IN-2 inhibits LPS (HY-D1056)- and IFN-γ-induced expression of IL-1β, IL-6, and TNF-α, and suppresses the JNK, ERK, and NF-κB signaling pathways. β5i-IN-2 can be used in research related to rheumatoid arthritis and ulcerative colitis .
Cat. No.: HY-N0668R
CAS No.: 64849-39-4
Category:
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
