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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
265 Results for "
Folate
" in MedChemExpress (MCE) Product Catalog:
Products (265)
265 Results for "Folate" in MCE Product Catalog:
Cat. No.: HY-D2888H
Synonyms: Rhodamine B-PEG10000-FA
Synonyms: L-5,6,7,8-Tetrahydrofolic acid (Standard); L-Tetrahydrofolic acid (Standard)
Cat. No.: HY-W042216
CAS No.: 515-74-2
Synonyms: Sodium 4-aminobenzenesulfonate
Sodium Sulphanilate (Sodium 4-aminobenzenesulfonate) is a folic acid synthetase inhibitor and antifungal agent, as well as a structural analog of p-aminobenzoic acid, that competitively inhibits folate biosynthesis in fungal pathogens. Sodium Sulphanilate induces host disease resistance via changes in amino acid profiles, reduces chlorophyll content in peanut leaves at high concentrations, and controls rust diseases in various plant species. Sodium Sulphanilate is applicable to studies related to peanut rust .
Target:
Cycloguanil (Chlorguanide triazine) is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .
Cat. No.: HY-149958
CAS No.: 2934738-40-4
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
Cat. No.: HY-B0688S1
CAS No.: 1346602-12-7
Synonyms: 4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
Cat. No.: HY-P992510
CAS No.: 3066905-22-1
Synonyms: LY-4170156 Antibody; MBK-103 Antibody
Target:
Domaines de recherche:
Sofetabart (LY-4170156 Antibody) is a humanized IgG1 antibody that specifically targets folate receptor α (FRα). Sofetabart can be used to synthesize the antibody-drug conjugate (ADC) Sofetabart mipitecan. Sofetabart is applicable to research related to advanced ovarian cancer, platinum-resistant epithelial ovarian cancer, fallopian tube cancer or primary peritoneal cancer, as well as platinum-sensitive ovarian cancer .
Cat. No.: HY-B0322AR
CAS No.: 4563-84-2
Synonyms: Ro 4-2130 sodium (Standard)
Target:
Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) sodium is the analytical standard of Sulfamethoxazole sodium (HY-B0322A). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) sodium is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole sodium inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole sodium can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
Target:
Domaines de recherche:
Sulfamethoxazole (Standard) (Ro 4-2130 (Standard)) is the analytical standard of Sulfamethoxazole (HY-B0322). This product is intended for research and analytical applications. Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis.
Cat. No.: HY-P705525
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC46A1; Heme Carrier Protein 1; Solute Carrier Family 46 Member 1; Solute Carrier Family 46 (Folate Transporter), Member 1; Proton-Coupled Folate Transporter; MGC9564; HsPCFT; G21; HPCFT; Solute Carrier Family 46, Member 1; HCP1; PCFT/HCP1; PCFT
Species:
Human
Source:
HEK293
Cat. No.: HY-10819
CAS No.: 177575-17-6
Target:
Domaines de recherche:
AG2034 is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), with a Ki of 28 nM against human GARFT, and it binds with high affinity to the folate receptor (Kd of 0.0042 nM). Additionally, AG2034 is a substrate for rat liver folylpolyglutamate synthetase, with a Km of 6.4 µM. AG2034 inhibits the growth of L1210 and CCRF-CEM cells, with IC50 values of 4 nM and 2.9 nM, respectively, and it has demonstrated antitumor activity in xenograft models such as 6C3HED .
Cat. No.: HY-14520S1
Synonyms: L-5,6,7,8-Tetrahydrofolic acid-13C5; L-Tetrahydrofolic acid-13C5
Cat. No.: HY-155845
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC50 of 0.0198-0.096 μM .
Cat. No.: HY-185427
Synonyms: IMGN-151
Domaines de recherche:
Opugotamig olatansine (IMGN151) is a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC). Opugotamig olatansine comprises antibody Opugotamig (HY-P990935) and linker-payload NMS-P945 (HY-185569). Opugotamig olatansine binds to two independent epitopes of FRα and promotes antibody binding, internalization, and processing. Opugotamig olatansine can be used for the research of FRα-positive ovarian cancer .
Cat. No.: HY-B0322S1
CAS No.: 1196157-90-0
Synonyms: Ro 4-2130-13C6
Synonyms: 4,4′-Diaminodiphenyl sulfone (Standard); DDS (Standard)
Domaines de recherche:
Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
Cat. No.: HY-P992520
Target:
Domaines de recherche:
Anti-FOLR2 Antibody is a specific antibody targeting folate receptor β (FOLR2). Anti-FOLR2 Antibody effectively detects intracellular and extracellular FOLR2 expression in flow cytometry and confocal microscopy experiments, facilitating the precise detection and isolation of FOLR2+ macrophages in breast cancer. Anti-FOLR2 Antibody is also widely used in studies on the mechanisms, diagnosis and treatment of chronic lymphocytic leukemia (CLL) .
Cat. No.: HY-127009
CAS No.: 68538-85-2
Synonyms: Levofolinic acid; Levofolene
Target:
-
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
