TYR

Isotope-Labeled Compounds Amyloid-β

β-Amyloid- ¹⁵N (1-42), human (TFA) is the ¹⁵N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .

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β-Amyloid (1-42), human, Ala(13C3,15N) TFA

Cat. No.: HY-P1363S1

Target:

Research Areas:

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

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Hongotoxin-1

Cat. No.: HY-P3014

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Research Areas:

Hongotoxin-1, isolated from venom of Centruroides limbatus, is the inhibitor of potassium channel, with IC₅₀ for? Kv1.1, Kv1.2, Kv1.3, and Kv1.6 of 31 pM, 170 pM, 86 pM,and 6000 pM, respectively .

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Slotoxin

Cat. No.: HY-P3111

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Slotoxin, a peptide from Centruroides noxius Hoffmann scorpion venom, blocks high conductance calcium-activated potassium channel, with K_d of 1.5 nM_[1].

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Dalazatide

Cat. No.: HY-P3507

CAS No.: 1081110-69-1

Synonyms: ShK-186

Target:

Metabolic Disease Inflammation/Immunology

Research Areas:

Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease .

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Dalazatide TFA

Cat. No.: HY-P3507A

Synonyms: ShK-186 TFA

Target:

Metabolic Disease Inflammation/Immunology

Research Areas:

Dalazatide (ShK-186) TFA is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide TFA can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease .

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5-FAM-Amylin (human)

Cat. No.: HY-P4732

CAS No.: 1678414-71-5

Target:

Biochemical Assay Reagents

Research Areas:

Biochemical Assay Reagents

5-FAM-Amylin (human) is a fluorescently labeled peptide derived from human amylin, which is involved in glucose metabolism. 5-FAM-Amylin (human) is an important tool in biochemical research, especially in studies of amyloid fibril formation .

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6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK)

Cat. No.: HY-P4742

CAS No.: 1927927-42-1

Synonyms: 6-FAM-AEEAC-SHK

Target:

Research Areas:

Biochemical Assay Reagents Potassium Channel

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) (6-FAM-AEEAC-SHK) is a polypeptide that can be used as a Biochemical Assay Reagents.

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6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA

Cat. No.: HY-P4742A

Synonyms: 6-FAM-AEEAC-SHK TFA

Target:

Research Areas:

6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA (6-FAM-AEEAC-SHK TFA) is a peptide neurotoxin conjugated with a fluorescent marker. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can block voltage-gated potassium channels (kv1.1 and kv1.2) to prolong the duration of action potentials, thereby affecting the conduction of neural signals. 6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) TFA can be used in neuroscience research .

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Biotinyl-Ahx-Amyloid β-Protein (1-42)

Cat. No.: HY-P4861

CAS No.: 1872440-40-8

Target:

Amyloid-β

Research Areas:

Biotinyl-Ahx-Amyloid β-Protein (1-42) is abiotinylated β-Amyloid (1-42), human (TFA) (HY-P1363).

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FITC-β-Ala-Amyloid β-Protein (1-42)

Cat. No.: HY-P5096

CAS No.: 1802087-77-9

Target:

Amyloid-β

Research Areas:

Insecticide Calcium Channel Apoptosis Necroptosis

FITC-β-Ala-Amyloid β-Protein (1-42) is a FITC tagged Aβ1-42 peptide. Aβ1-42 plays a key role in the pathogenesis of Alzheimer’s disease .

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ω-Hexatoxin-Hv1a

Cat. No.: HY-P5142

CAS No.: 193981-10-1

Synonyms: ω-ACTX-Hv1; ω-Atracotoxin-HV1

Target:

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .

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ω-Hexatoxin-Hv1a TFA

Cat. No.: HY-P5142A

Synonyms: ω-ACTX-Hv1 TFA; ω-Atracotoxin-HV1 TFA

Target:

Insecticide Apoptosis Calcium Channel Necroptosis

Research Areas:

Cardiovascular Disease Neurological Disease Inflammation/Immunology

ω-Hexatoxin-Hv1a (ω-ACTX-Hv1; ω-Atracotoxin-HV1) TFA is an orally active insecticidal neurotoxin containing an inhibitor cystine knot motif and a selective calcium channel inhibitor. ω-Hexatoxin-Hv1a TFA blocks L-type voltage-dependent Ca ²⁺ channels and reduces intracellular calcium ion concentration, thereby decreasing apoptosis, necroptosis and oxidative stress, and promoting cell recovery and energy level elevation. ω-Hexatoxin-Hv1a TFA causes larval paralysis and death by impairing neurotransmission in the central nervous system of insects. It shows high injectable toxicity against insects of multiple orders, but exhibits weak oral toxicity. ω-Hexatoxin-Hv1a TFA is widely applicable to studies related to ischemia-reperfusion injury, atopic dermatitis, and ischemic injury of cardiomyocytes and neurons .

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FC382K10W15

Cat. No.: HY-P5161

Target:

GLP Receptor GCGR

Research Areas:

Metabolic Disease

FC382K10W15 is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 can be used in type 2 diabetes research .

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FC382K10W15 TFA

Cat. No.: HY-P5161A

Target:

GLP Receptor GCGR

Research Areas:

Metabolic Disease

FC382K10W15 TFA is a glucagon analogue and GLP-1R/GCGR agonist. FC382K10W15 TFA can be used in type 2 diabetes research .

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HsTX1

Cat. No.: HY-P5182

CAS No.: 201948-00-7

Target:

Research Areas:

Inflammation/Immunology

HsTX1, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1, an the inhibitor of potassium channel, with IC₅₀ for Kv1.3 of 12 pM inhibits T_EM cell activation and attenuates inflammation in autoimmunity .

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HsTX1 TFA

Cat. No.: HY-P5182A

Target:

Research Areas:

Inflammation/Immunology

HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC₅₀ for Kv1.3 of 12 pM and inhibits T_EM cell activation and attenuates inflammation in autoimmunity .

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Hainantoxin-IV

Cat. No.: HY-P5184

CAS No.: 651782-02-4

Synonyms: HNTX-IV

Target:

Sodium Channel

Research Areas:

Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

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Palicourein

Cat. No.: HY-P5738

CAS No.: 331714-57-9

Target:

Bacterial

Research Areas:

Infection

Palicourein is a 37 amino acid cyclic polypeptide. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC₅₀ value of 0.1 μM and an IC₅₀ value of 1.5 μM .

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Aa1 toxin

Cat. No.: HY-P5854

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Research Areas: