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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
142 Results for "
DNA intercalating
" in MedChemExpress (MCE) Product Catalog:
Products (142)
142 Results for "DNA intercalating" in MCE Product Catalog:
1
Target:
10-Methoxy-canthin-6-one (Mtx-C) is analkaloid derivative. 10-Methoxy-canthin-6-one can induce DNA damage by intercalating into DNA. 10-Methoxy-canthin-6-one can inhibit cancer cells proliferation, cause G2/M phase arrest and induce myeloid differentiation. T10-Methoxy-canthin-6-one can upregulate the expression of myeloperoxidase, CD15, CD11b, and CD14, as well as activation of p38 MAPK. 10-Methoxy-canthin-6-one also exhibits anti-bacterial activity. 10-Methoxy-canthin-6-one can be used for the researches of cancer and infection, such as acute myeloid leukemias (AML) .
Art. -Nr.: HY-U00248A
CAS. Nr.: 308246-57-3
Synonyms: MJ-III65 hydrochloride; NSC706744 hydrochloride
Target:
Forschungsgebiete:
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .
Art. -Nr.: HY-U00248
CAS. Nr.: 308246-52-8
Synonyms: MJ-III65; NSC706744
Target:
Forschungsgebiete:
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .
Category:
Infection Quinones Anthraquinones Phenols Polyphenols Plants Solanaceae Disease Research Fields Rhizophora mucronata Lam
Target:
Synonyms: BQQ
Target:
Forschungsgebiete:
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure .
Art. -Nr.: HY-D1322
CAS. Nr.: 2375105-86-3
Art. -Nr.: HY-D1773
CAS. Nr.: 156312-20-8
Art. -Nr.: HY-13550
CAS. Nr.: 64862-96-0
Synonyms: NSC 196473; NSC 290813
Target:
Forschungsgebiete:
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .
Art. -Nr.: HY-W111005
CAS. Nr.: 1086-00-6
Target:
Forschungsgebiete:
1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .
Art. -Nr.: HY-W110980
CAS. Nr.: 613-13-8
Synonyms: Anthracen-2-amine; 2-Anthramine
Art. -Nr.: HY-13727
CAS. Nr.: 144510-96-3
Synonyms: BBR 2778 free base
Target:
Forschungsgebiete:
Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity.
Art. -Nr.: HY-19829
CAS. Nr.: 100940-65-6
Category:
Infection Microorganisms Antibiotics Disease Research Antibacterial Anticancer Disease Research Fields Other Antibiotics
Target:
Art. -Nr.: HY-U00337
CAS. Nr.: 105118-14-7
Target:
Forschungsgebiete:
Datelliptium chloride is a DNA-intercalating agent derived from ellipticine, with anti-tumor activities.
Art. -Nr.: HY-D1095
CAS. Nr.: 1268616-88-1
Art. -Nr.: HY-105293
CAS. Nr.: 910229-23-1
Target:
Forschungsgebiete:
NSC 727357 is a DNA intercalator and topoisomerase inhibitor with antitumor activity. NSC 727357 can inhibit cells proliferation and induce G1 phase arrest. NSC 727357 can be used for the research of cancer, such as melanoma .
Art. -Nr.: HY-13727B
CAS. Nr.: 175989-38-5
Synonyms: BBR 2778 hydrochloride
Target:
Forschungsgebiete:
Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity .
Art. -Nr.: HY-W016840
CAS. Nr.: 14510-06-6
Art. -Nr.: HY-D1246
CAS. Nr.: 58880-05-0
Art. -Nr.: HY-124122
CAS. Nr.: 1802665-43-5
Forschungsgebiete:
BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC50 values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC50 value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
