531-53-3
Chemical Structure
Azure A chloride
- CAS No.: 531-53-3
- Formula:C14H14ClN3S
- Molecular Weight:291.81
IUPAC Name: 3-amino-7-(dimethylamino)phenothiazin-5-ium chloride
InChIKey: PGWTYMLATMNCCZ-UHFFFAOYSA-M
SMILES: CN(C1=CC2=[S+]C3=C(C=CC(N)=C3)N=C2C=C1)C.[Cl-]
Biological Activity: Azure A chloride is a phenothiazine dye. Azure A chloride is an alternative DNA dye used for the separation of DNA and protein fragments in agarose gel electrophoresis and PAGE. Azure A chloride can be chemisorbed on the surface of mild steel according to the Langmuir adsorption isotherm to form a protective film. Azure A chloride binds to double-stranded DNA in a non-cooperative manner via weak intercalation, triggering molecular conformational disturbance, restricted rotational motion, and changes in optical activity[1][2][3].
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Azure A chloride | 70% | Azure A chloride is a phenothiazine dye. Azure A chloride is an alternative DNA dye used for the separation of DNA and protein fragments in agarose gel electrophoresis and PAGE. Azure A chloride can be chemisorbed on the surface of mild steel according to the Langmuir adsorption isotherm to form a protective film. Azure A chloride binds to double-stranded DNA in a non-cooperative manner via weak intercalation, triggering molecular conformational disturbance, restricted rotational motion, and changes in optical activity. | ||||||||||||||||||||
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References
- [1]. M. Snehalatha, et al. Azure A chloride: computational and spectroscopic study. J. Raman Spectrosc. 2009, 40, 176-182.
- [2]. Demet Özkır, et al. The inhibition effect of Azure A on mild steel in 1 M HCl. A complete study: Adsorption, temperature, duration and quantum chemical aspects. Corrosion Science 56 (2012) 143-152.
- [3]. Paul P, et al. Spectroscopic studies on the binding interaction of phenothiazinium dyes toluidine blue O, azure A and azure B to DNA. Spectrochim Acta A Mol Biomol Spectrosc. 2013;107:303-310. [Content Brief]
