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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
MD-2
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "MD-2" in MCE Product Catalog:
Cat. No.: HY-N0795R
CAS No.: 20315-25-7
Cat. No.: HY-179036
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APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50 of 24.2 μg/mL). APG-7 is an Apigenin (HY-N1201) derivative. APG-7 has low toxicity to the 3T3 fibroblast cell line. APG-7 can be used for the study of oxidative stress and inflammation .
Cat. No.: HY-149248
CAS No.: 2924565-59-1
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NF-κB-IN-8 competitively antagonizes LPS binding to MD-2. NF-κB-IN-8 reduces the expression of inflammatory factors by binding to MD-2. NF-κB-IN-8 also inhibits ALP activity. NF-κB-IN-8 can be used for the research of inflammation such as acute lung injury (ALI) .
Cat. No.: HY-103483R
CAS No.: 111797-22-9
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MD2-IN-1 (Standard) is the analytical standard of MD2-IN-1 (HY-103483). This product is intended for research and analytical applications. MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a Kd of 189 μM for the recombinant human MD2 (rhMD2).
Cat. No.: HY-P5117
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Cat. No.: HY-W014223R
CAS No.: 131-56-6
Synonyms: Ultraviolet absorber UV-0 (Standard)
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2,4′-Dihydroxybenzophenone (Standard) is the analytical standard of 2,4′-Dihydroxybenzophenone. This product is intended for research and analytical applications. 2,4′-Dihydroxybenzophenone (Ultraviolet absorber UV-0) occupies the hydrophobic pocket of MD2 and blocks the dimerization of TLR4. 2,4′-Dihydroxybenzophenone inhibits the LPS induced mtROS production, and LPS induced inflammatory response by downregulating pro-inflammatory mediators and decreasing the expression of MyD88, p-IRAK4, and NF-κB. 2,4′-Dihydroxybenzophenone is also a UV absorber [2].
Cat. No.: HY-RS26109
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Ly96 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ly96 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07908
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LY96 Human Pre-designed siRNA Set A contains three designed siRNAs for LY96 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-N2345R
CAS No.: 23567-23-9
Cat. No.: HY-P11580
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Cat. No.: HY-17417E
CAS No.: 65700-73-4
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(+)-Naloxone is a TLR4 inhibitor and the dextrorotatory enantiomer of the non-opioid Naloxone (HY-17417A) that lacks opioid receptor binding activity. (+)-Naloxone binds to MD2, preventing LPS from binding to TLR4, thereby inhibiting TLR4 signaling, downstream NFκB activation, and proinflammatory cytokine synthesis. (+)-Naloxone crosses the placenta. (+)-Naloxone is used in the research of preterm birth .
Cat. No.: HY-N19801
CAS No.: 54627-18-8
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Cat. No.: HY-RS19614
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Ly96 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ly96 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182034
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GAP214 is a monosaccharide lipid A analogue and TLR4/MD-2 complex modulator.GAP214 binds to the TLR4/MD-2 complex via hydrophobic interactions, salt bridges, and hydrogen bonds, induces dimerization of the complex to initiate intracellular signaling cascades.GAP214 functions as an immunostimulant and vaccine adjuvant, enhances antigen-specific IgG antibody production in a mouse model .
Cat. No.: HY-P810361
Synonyms: Homolog of REV7 S cerevisiae, hREV7, MAD2 (mitotic arrest deficient yeast, homolog) like 2, MAD2 homolog, MAD2 like 2, MAD2 mitotic arrest deficient like 2, MAD2-like protein 2, MAD2B, Mad2l2, MD2L2_HUMAN
Cat. No.: HY-P811869
Synonyms: SH3RF1; SH3 Domain Containing Ring Finger 1; RNF142; POSH; KIAA1494; SH3MD2; SH3 Domain-Containing RING Finger Protein 1; RING-Type E3 Ubiquitin Transferase SH3RF1; E3 Ubiquitin-Protein Ligase SH3RF1; SH3 Multiple Domains Protein 2; SH3 Multiple Domains 2; Plenty Of SH3 Domains; Plenty Of SH3s; Putative E3 Ubiquitin-Protein Ligase SH3RF1; Ring Finger Protein 142; RING Finger Protein 142; Protein POSH; EC 2.3.2.27; EC 6.3.2; POSH1
Cat. No.: HY-P811869A
Synonyms: SH3RF1; SH3 Domain Containing Ring Finger 1; RNF142; POSH; KIAA1494; SH3MD2; SH3 Domain-Containing RING Finger Protein 1; RING-Type E3 Ubiquitin Transferase SH3RF1; E3 Ubiquitin-Protein Ligase SH3RF1; SH3 Multiple Domains Protein 2; SH3 Multiple Domains 2; Plenty Of SH3 Domains; Plenty Of SH3s; Putative E3 Ubiquitin-Protein Ligase SH3RF1; Ring Finger Protein 142; RING Finger Protein 142; Protein POSH; EC 2.3.2.27; EC 6.3.2; POSH1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
