TAT-CIRP
TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice.
For research use only. We do not sell to patients.
- Formula: C123H206N56O33
- Molecular Weight:2997.31
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TAT-CIRP (5 μM) alleviates apoptosis and necroptosis induced by NMDA stimulation (50 μM; 1 h), through a TLR4-independent pathway, in neuronal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TAT-CIRP (20 mg/kg; iv; single dose) can pass through the blood-brain barrier (BBB) in mice, with Cmax value of 4762.6 μg/L, and half-life about 90 min[1].
TAT-CIRP (20 mg/kg, 100 mg/kg; iv; once daily for 7 days) induces little toxicity in mice, with safety profile[1].
TAT-CIRP reduces cerebral ischemic injury in rhesus monkey[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Middle cerebral artery (MCA) occlusion (MCAO) model in mouse[1]
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Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg
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Administration:IV; single dose or once daily for 7 days
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Result:Resulted better neurological function at 28 days after brain hemorrhage than the mice that received saline.
Did not induce elevation of any liver transaminases or biomarkers of renal dysfunction.
Chemical Information
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Appearance Solid
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Molecular Weight 2997.31
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Formula C123H206N56O33
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Color White to off-white
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Sequence
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly
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Sequence Shortening
YGRKKRRQRRRGRGFSRGGGDRGYGG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAT-CIRP Related Classifications
HY-P5117 Related Classifications
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