2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TAT-CIRP

TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice.

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TAT-CIRP Chemical Structure

TAT-CIRP Chemical Structure

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TAT-CIRP Related Antibodies

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Description

TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice[1].

In Vitro

TAT-CIRP (5 μM) alleviates apoptosis and necroptosis induced by NMDA stimulation (50 μM; 1 h), through a TLR4-independent pathway, in neuronal cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-CIRP Related Antibodies
In Vivo

TAT-CIRP (5-20mg/kg) alleviates brain damage after ischemic stroke in mice with middle cerebral artery (MCA) occlusion (MCAO). As for Tat, the cell membrane transduction domain of human immunodeficiency virus type 1, can be used as a control peptide[1].
TAT-CIRP (20 mg/kg; iv; single dose) can pass through the blood-brain barrier (BBB) in mice, with Cmax value of 4762.6 μg/L, and half-life about 90 min[1].
TAT-CIRP (20 mg/kg, 100 mg/kg; iv; once daily for 7 days) induces little toxicity in mice, with safety profile[1].
TAT-CIRP reduces cerebral ischemic injury in rhesus monkey[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Middle cerebral artery (MCA) occlusion (MCAO) model in mouse[1]
Dosage: 5 mg/kg, 10 mg/kg, 20 mg/kg
Administration: IV; single dose or once daily for 7 days
Result: Resulted better neurological function at 28 days after brain hemorrhage than the mice that received saline.
Did not induce elevation of any liver transaminases or biomarkers of renal dysfunction.
Molecular Weight

2997.31

Formula

C123H206N56O33
Appearance

Solid

Color

White to off-white

Sequence

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly
Sequence Shortening

YGRKKRRQRRRGRGFSRGGGDRGYGG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Purity & Documentation
References
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TAT-CIRP Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAT-CIRPToll-like Receptor (TLR)Trans-trans-activatingcold-inducible RNA binding proteinmyeloid differentiation protein 2neuronal injuryneuroprotection against ischemichemorrhagic strokeblood-brain barrierInhibitorinhibitorinhibit

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