615 Results for "

RA

" in MedChemExpress (MCE) Product Catalog:
Products (615)

615 Results for "RA" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P990034
CAS No.: 1202526-59-7
Synonyms: MLTA3698A; RG7415; PRO283698

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Pateclizumab (MLTA3698A) is a humanized antibody against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis .
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2
2 Cited Publications
Cat. No.: HY-111532
CAS No.: 1359752-95-6
Purity:  99.73%
Target:  

ClpP Bacterial

Research Areas:  

Infection

(3R,4R)-A2-32-01 (compound 24(R,R)), the (R,R)-enantiomer of A2-32-01, is a Staphylococcus aureus caseinolytic protease (SaClpP) inhibitor .
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2
2 Cited Publications
Cat. No.: HY-P71963
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL17RA; Interleukin-17 Receptor A; Prev. IL17R; Interleukin 17 Receptor; IL-17RA; CD217 Antigen; CDw217; CANDF5; HIL-17R; IMD51; CD217; Interleukin 17 Receptor A; IL-17 Receptor A
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-118530
CAS No.: 65002-17-7
Purity:  98.87%
Synonyms: SA96; Thiobutarit
Target:  

VEGFR

Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
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2
2 Cited Publications
Cat. No.: HY-P10136
Synonyms: human TREM-2 182-190
Target:  

TREM receptor

Research Areas:  

Inflammation/Immunology

IA9 (human TREM-2 182-190) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 can be used for neuroinflammation PET imaging. IA9 can be used for Rheumatoid arthritis (RA) and neuroinflammation research .
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2
2 Cited Publications
Cat. No.: HY-P10136A
Synonyms: human TREM-2 182-190 TFA
Target:  

TREM receptor

Research Areas:  

Inflammation/Immunology

IA9 TFA (human TREM-2 182-190 TFA) is a potent, CNS-penetrant TREM-2 inhibitor. IA9 TFA can diminish the release of proinflammatory cytokines and suppress joint inflammation and damage in a Collagen (HY-P5003)-induced arthritis (CIA) mouse model. IA9 TFA can be used for neuroinflammation PET imaging. IA9 TFA can be used for Rheumatoid arthritis (RA) and neuroinflammation research .
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2
2 Cited Publications
Cat. No.: HY-P7223
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL6R; IL-6R 1; Interleukin 6 Receptor; IL-6RA; Gp80; Interleukin 6 Receptor Subunit Alpha; Interleukin-6 Receptor Subunit Alpha; IL-6R Subunit Alpha; MembRAne Glycoprotein 80; IL-6R-Alpha; IL-1RA; IL-6R-1; IL6RA; IL6QTL; IL-6R; IL6RQ; CD126; HIES5; IL-6 Receptor Subunit Alpha; IL6Q; CD126 Antigen
Species:  
Human
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-147141
CAS No.: 2767422-72-8
Purity:  98.93%
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .
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2
2 Cited Publications
Cat. No.: HY-P77007
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL36RN; IL-1RA Homolog 1; Prev. IL1F5; IL-36RA; IL1HY1; IL-1F5 (IL-1HY1, FIL1-Delta, IL-1RP3, IL-1L1, IL-1-Delta); IL1RP3; IL1F5 (Canonical Product IL-1F5a); FIL1D; Family Of Interleukin 1-Delta; IL1L1; Interleukin-1 Family Member 5; Interleukin-1 Recepto
Species:  
Mouse
Source:  
E. coli
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1
1 Cited Publications
Cat. No.: HY-P9923A
CAS No.: 1044511-01-4
Synonyms: MEDI-563 (anti-IL5RA); BIW-8405 (anti-IL5RA); KHK4563 (anti-IL5RA)
Benralizumab (anti-IL5RA) (MEDI-563 (anti-IL5RA); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .
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1
1 Cited Publications
Cat. No.: HY-108522
CAS No.: 457657-34-0
Purity:  98.48%
Target:  

RAR/RXR

Research Areas:  

Metabolic Disease

PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development .
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1
1 Cited Publications
Cat. No.: HY-P2171A
Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
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1
1 Cited Publications
Cat. No.: HY-P10284
CAS No.: 853248-13-2
S7 is an inhibitory polypeptide targeting IL-6R, which specifically binds to IL-6R and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .
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1
1 Cited Publications
Cat. No.: HY-P70655
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL15RA; IL-15 Receptor Subunit Alpha; Interleukin 15 Receptor Subunit Alpha; IL15RA Protein; Interleukin-15 Receptor Subunit Alpha; CD215 Antigen; IL-15RA; IL-15R-Alpha; CD215; Il15RA; Interleukin 15 Receptor, Alpha; IL15; Interleukin-15; Interleukin 15;
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-15427
CAS No.: 1133432-49-1
Purity:  98.05%
Target:  

Btk

Research Areas:  

Inflammation/Immunology Cancer

GDC-0834 is an orally active selective, potent, and reversible BTK inhibitor with an IC50 of 5.9 nM. GDC-0834 demonstrates pBTK-Tyr223 inhibition in mice and rats. GDC-0834 can be used for research of rheumatoid arthritis (RA) .
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1
1 Cited Publications
Cat. No.: HY-P99287
CAS No.: 468715-71-1
Synonyms: B-E8; Anti-IL-6 MAB B-E8

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) .
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1
1 Cited Publications
Cat. No.: HY-P99259
CAS No.: 1613144-80-1
Synonyms: FPA 008; Anti-Human CSF1R Recombinant Antibody

Target:  

c-Fms

Research Areas:  

Inflammation/Immunology Cancer

Cabiralizumab (FPA 008) is an anti-CSF1R monoclonal antibody (MAb). Cabiralizumab enhances T cell infiltration and antitumor T cell immune responses. Cabiralizumab inhibits the activation of osteoclasts and blocks bone destruction, and can be used in the research of rheumatoid arthritis (RA). Cabiralizumab can combine with Nivolumab (HY-P9903) for lung cancer research .
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1
1 Cited Publications
Cat. No.: HY-125099A
Purity:  99.83%
AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 μM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 μM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis .
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1
1 Cited Publications
Cat. No.: HY-P10935A
Synonyms: 5-MP TFA
Research Areas:  

Inflammation/Immunology

Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases .
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1
1 Cited Publications
Cat. No.: HY-P7220
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL4R; IL4RA; Interleukin 4 Receptor; Interleukin-4 Receptor Alpha Chain; Interleukin-4 Receptor Subunit Alpha; IL-4R Subunit Alpha; CD124; IL4R Nirs Variant 1; IL-4 Receptor Subunit Alpha; CD124 Antigen; Interleukin 13 Receptor; IL-4R-Alpha; IL-4RA
Species:  
Human
Source:  
HEK293
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