10215 Results for "

activity

" in MedChemExpress (MCE) Product Catalog:
Products (10215)

10215 Results for "activity" in MCE Product Catalog:

68
68 Cited Publications
Cat. No.: HY-13067
CAS No.: 34157-83-0
Purity:  99.64%
Synonyms: Tripterine; Tripterin
Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .
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67
67 Cited Publications
Cat. No.: HY-N0184
CAS No.: 1405-86-3
Synonyms: Glycyrrhizin
Glycyrrhizic acid is a triterpenoid saponinl, acting as a direct HMGB1 antagonist, with anti-tumor, anti-diabetic activities.
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67
67 Cited Publications
Cat. No.: HY-76225
CAS No.: 53956-04-0
Synonyms: Monoammonium glycyrrhizinate; Glycyrrhizic acid ammonium salt; Ammonium glycyrrhizate
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
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67
67 Cited Publications
Cat. No.: HY-N0184A
CAS No.: 68797-35-3
Synonyms: Glycyrrhizic acid dipotassium; Dipotassium glycyrrhizate
Dipotassium glycyrrhizinate is a HMGB1 inhibitor, inhibits atopic dermatitis-related gene expression with anti-anti-inflammatory activity .
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64
64 Cited Publications
Cat. No.: HY-12289
CAS No.: 1073154-85-4
Purity:  99.87%
Synonyms: VS-6063; PF-04554878
Target:  

FAK

Research Areas:  

Cancer

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.
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64
64 Cited Publications
Cat. No.: HY-15145A
CAS No.: 2468639-77-0
Purity:  99.19%
Target:  

Sirtuin Autophagy

Research Areas:  

Metabolic Disease

SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .
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64
64 Cited Publications
Cat. No.: HY-15145
CAS No.: 2060259-60-9
Purity:  99.37%
Target:  

Sirtuin Autophagy

Research Areas:  

Metabolic Disease

SRT 1720 monohydrochloride is a selective and orally active activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 .
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62
62 Cited Publications
Cat. No.: HY-B0434
CAS No.: 36791-04-5
Synonyms: Ribasphere
Research Areas:  

Infection Cancer

Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities.
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61
61 Cited Publications
Cat. No.: HY-B0356
CAS No.: 85721-33-1
Synonyms: Bay-09867
Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin has anti-proliferative activity and induces apoptosis. Ciprofloxacin is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity .
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60
60 Cited Publications
Cat. No.: HY-13004
CAS No.: 376348-65-1
Purity:  99.88%
Synonyms: UK-427857
Target:  

CCR HIV

Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.
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57
57 Cited Publications
Cat. No.: HY-111783
CAS No.: 2230820-11-6
Purity:  99.86%
Research Areas:  

Cancer

AZD-7648 is a potent, orally active, selective DNA-PK inhibitor with an IC50 of 0.6 nM. AZD-7648 induces apoptosis and shows antitumor activity .
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56
56 Cited Publications
Cat. No.: HY-A0107
CAS No.: 60-54-8
Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections .
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56
56 Cited Publications
Cat. No.: HY-B0474
CAS No.: 64-75-5
Tetracycline hydrochloride is a broad-spectrum antibiotic with oral activity. Tetracycline hydrochloride exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline hydrochloride can be used for the research of infections .
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53
53 Cited Publications
Cat. No.: HY-15845
CAS No.: 307543-71-1
Purity:  ≥98.0%
Target:  

IRE1

Research Areas:  

Cancer

STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
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53
53 Cited Publications
Cat. No.: HY-10159
CAS No.: 641571-10-0
Purity:  99.94%
Synonyms: AMN107
Target:  

Bcr-Abl Autophagy

Research Areas:  

Cancer

Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
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53
53 Cited Publications
Cat. No.: HY-10320A
CAS No.: 1283526-53-3
Synonyms: BIRB 796 hydrochloride
Target:  

Autophagy Raf p38 MAPK

Research Areas:  

Inflammation/Immunology

Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases .
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53
53 Cited Publications
Cat. No.: HY-10159B
CAS No.: 923288-95-3
Synonyms: AMN107 hydrochloride
Target:  

Bcr-Abl Autophagy

Research Areas:  

Cancer

Nilotinib (AMN107) hydrochloride is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia .
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53
53 Cited Publications
Cat. No.: HY-10159C
Synonyms: AMN107 hydrochloride dihydrate
Target:  

Autophagy Bcr-Abl

Research Areas:  

Cancer

Nilotinib (AMN107) hydrochloride dihydrate is an orally active Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity and can be used in studies of chronic myelogenous leukaemia .
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52
52 Cited Publications
Cat. No.: HY-K1090

MCE Cytotoxicity LDH Assay Kit can detect LDH activity in the culture supernatant, which is indicative of cytotoxicity.

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49
49 Cited Publications
Cat. No.: HY-13502
CAS No.: 65271-80-9
Purity:  99.58%
Synonyms: Mitozantrone; NSC 301739
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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