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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
headache
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "headache" in MCE Product Catalog:
Cat. No.: HY-119121
CAS No.: 951135-00-5
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JNJ-38893777 is an orally active and highly selective transient receptor potential vanilloid type 1 (TRPV1) channel antagonist. JNJ-38893777 inhibits neuronal hyperactivation and reduces inflammatory hyperalgesia. JNJ-38893777 is promising for research of migraine headaches, neuropathic and inflammatory pain .
Cat. No.: HY-B1658
CAS No.: 158747-02-5
Synonyms: (R)-Frovatriptan; SB 209509; VML 251
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Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura .
Cat. No.: HY-B0804R
CAS No.: 42200-33-9
Synonyms: SQ-11725 (Standard)
Research Areas:
Nadolol (Standard) is the analytical standard of Nadolol. This product is intended for research and analytical applications. Nadolol (SQ-11725) is a non-selective and orally active β-adrenergic receptors blocker and is a substrate of organic anion transporting polypeptide 1A2 (OATP1A2). Nadolol has the the potential for high blood pressure, angina pectoris and vascular headaches research .
Cat. No.: HY-10585AS1
Purity: 96.45%
Synonyms: Sodium Valproate-d14; VPA-d14 sodium; 2-Propylpentanoic acid-d14 sodium
Cat. No.: HY-10585AS
CAS No.: 1189994-89-5
Synonyms: Sodium Valproate-d7; VPA-d7 sodium; 2-Propylpentanoic acid-d7 sodium
Cat. No.: HY-10585S3
Synonyms: Sodium Valproate-d4; VPA-d4 sodium; 2-Propylpentanoic acid-d4 sodium
Cat. No.: HY-10585AG
CAS No.: 1069-66-5
Synonyms: Sodium Valproate (GMP); VPA sodium (GMP); 2-Propylpentanoic acid sodium (GMP)
Cat. No.: HY-W794759
CAS No.: 62959-43-7
Synonyms: Magnesium valproate; VPA magnesium; 2-Propylpentanoic acid magnesium
Research Areas:
Valproic acid magnesium (Magnesium valproate) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM. Valproic acid magnesium inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid magnesium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid magnesium is used in the epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .
Cat. No.: HY-B0121R
CAS No.: 103628-48-4
Synonyms: GR 43175 succinate (Standard)
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Sumatriptan (succinate) (Standard) is the analytical standard of Sumatriptan (succinate). This product is intended for research and analytical applications. Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research .
Cat. No.: HY-B0121BR
CAS No.: 103628-46-2
Synonyms: GR 43175 free base (Standard)
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Sumatriptan (Standard) is the analytical standard of Sumatriptan. This product is intended for research and analytical applications. Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan can be used for migraine headache research .
Cat. No.: HY-W018475
CAS No.: 144034-80-0
Synonyms: MK 462 free base
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Rizatriptan (MK 462 free base) is an orally active 5-HT1B/5-HT1D receptor agonist, with BBB permeability. Rizatriptan exerts significant anti-migraine effects by constricting intracranial and extracranial blood vessels and inhibiting neuropeptide release. Rizatriptan exhibits species- and tissue-specific metabolic characteristics; for example, it undergoes oxidative deamination mainly by MAO-A in the liver of brown rats, so co-administration with MAO-A inhibitors is prohibited. Rizatriptan may also exacerbate nitroglycerin-induced cutaneous allodynia, prolong the duration of central sensitization, and increase anxiety-like behavior and active drug-seeking behavior in mice. Rizatriptan has been widely used in studies related to migraine and medication-overuse headache .
Cat. No.: HY-106736
CAS No.: 42145-91-5
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Etilefrine pivalate hydrochloride is an orally active compound and can be used for study of migraine headaches .
Cat. No.: HY-P2428
CAS No.: 95034-26-7
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Proxibarbal is a barbiturate derivative. Proxibarbal has anti-anxiety properties and is also used for the study of migraine headaches.
Cat. No.: HY-108200
CAS No.: 197077-52-4
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UK-315716 is an NMDA receptor antagonist. UK-315716 has a synergistic neuroprotective effect. UK-315716 can be used for research on neurological diseases such as stroke and headache .
Cat. No.: HY-110351
CAS No.: 1962928-26-2
Synonyms: PGN 1531 hydrochloride
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BGC 20-1531 (PGN 1531) hydrochloride is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC 20-1531 hydrochloride has the potential for the research of migraine headache .
Cat. No.: HY-19849
CAS No.: 736183-35-0
Synonyms: PGN 1531 free base
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Research Areas:
BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKB of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache .
Cat. No.: HY-N12081
CAS No.: 863329-68-4
Category:
Moraceae Extract Phenols Polyphenols Plants Morus alba Linn.
Target:
Cat. No.: HY-101202A
CAS No.: 1217643-87-2
Synonyms: (Rac)-NIH 10815
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(Rac)-SNC80 is a racemate of SNC80 (HY-101202). SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment .
Cat. No.: HY-B1658S
Synonyms: (R)-Frovatriptan-d3 hydrochloride; SB 209509-d3 hydrochloride; VML 251-d3 hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
