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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
mismatch
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "mismatch" in MCE Product Catalog:
Cat. No.: HY-P11732
Cat. No.: HY-179326
CAS No.: 2923008-65-3
Target:
Research Areas:
WRN-IN-23 is a Werner Syndrome helicase enzyme (WRN) inhibitor. WRN-IN-23 inhibits the ATP-dependent helicase domain activity of WRN. WRN-IN-23 can be used for the research of cancers characterized by microsatellite instability (MSI) and/or defective DNA mismatch repair system (dMMR) .
Cat. No.: HY-P87323
Synonyms: C JUN leucine zipper interactive protein antibody; C JUN leucine zipper interactive protein antibody; C-JUN leucine zipper interactive protein JZA-3 antibody; E130317C12Rik antibody; EC 3.2.2.29 antibody; G/T mismatch specific thymine DNA glycosylase antibody; G/T mismatch specific thymine DNA glycosylase antibody; G/T mismatch-specific thymine DNA glycosylase antibody; JZA 3 antibody; Jza1 antibody
Cat. No.: HY-P82029A
Synonyms: DNA mismatch repair protein Msh2; MutS protein homolog 2
Cat. No.: HY-129387
CAS No.: 2378640-25-4
Target:
Research Areas:
Perforin-IN-1 is a perforin inhibitor that blocks perforin-mediated lysis of target cells by cytotoxic lymphocytes. Perforin-IN-1 achieves perforin inhibition in a mouse bone marrow transplantation model, protecting MHC-mismatched allogeneic bone marrow stem cell grafts from NK cell-mediated rejection. Perforin-IN-1 can be used for research on graft rejection .
Cat. No.: HY-P811906
Synonyms: PMSL1, PMS1, PMS1 protein homolog 1, DNA mismatch repair protein PMS1
Cat. No.: HY-188137
Research Areas:
ASO-5005 is a 20-mer Gapmer antisense oligonucleotide modified with locked nucleic acids (LNA), featuring a full phosphorothioate backbone, which targets BCL2 mRNA and BCL2L1 mRNA. ASO-5005 downregulates Bcl-2 expression via an RNase H-dependent mechanism, with its sequence fully complementary to BCL2 mRNA; it simultaneously downregulates Bcl-xL expression via an RNase H-dependent mechanism, with three mismatches between its sequence and BCL2L1 mRNA, while LNA modification enhances its activity against this mismatched target. ASO-5005 induces Apoptosis by activating Caspase-3 and cleaving ICAD. ASO-5005 does not significantly regulate the expression of Bcl-W, Survivin, Akt, or p53 in tumor cells. ASO-5005 can be used for research on breast cancer and non-small cell lung cancer .
Cat. No.: HY-P702783
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TDG; Thymine-DNA Glycosylase; Thymine DNA Glycosylase; HTDG; G/T mismatch-Specific Thymine DNA Glycosylase; TDG Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P811906A
Synonyms: PMSL1, PMS1, PMS1 protein homolog 1, DNA mismatch repair protein PMS1
Cat. No.: HY-P85919
Synonyms: DNA mismatch repair protein Msh6; G/T mismatch binding protein; G/T mismatch-binding protein; GTBP; GTMBP; hMSH6; HNPCC 5; HNPCC5; HSAP; MSH 6; MSH6; MSH6_HUMAN; mutS; E. coli; homolog 6; MutS alpha 160 kDa subunit; MutS homolog 6; E. coli; mutS homolog 6; MutS-alpha 160 kDa subunit; p160; Sperm associated protein
Cat. No.: HY-17364S1
Synonyms: NSC 362856-15N; CCRG 81045-15N; TMZ-15N
Research Areas:
Temozolomide- 15N (NSC 362856- 15N) is the 15N-labeled Temozolomide (HY-17364). Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
Cat. No.: HY-115464
CAS No.: 150661-91-9
Target:
Research Areas:
NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .
Cat. No.: HY-P73803
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MSH2; Truncated MutS Homolog 2 Protein; Prev. COCA1; DNA mismatch Repair Protein; DNA mismatch Repair Protein Msh2; MutS Homolog 2 Protein; HNPCC1; MSH2+Ins9a Isoform; HNPCC; MSH2-Ex10 Isoform; MSH-2; MSH2-Ex5 Isoform; MutS Protein Homolog 2; MSH2-Ex3 Iso
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
