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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
EP1
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "EP1" in MCE Product Catalog:
Cat. No.: HY-177544
CAS No.: 330795-70-5
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EP1 receptor antagonist-1 (Compound Example 5a freebase) is an EP1 prostaglandin receptor antagonist. EP1 receptor antagonist-1 is promising for research of urinary system-related diseases [1].
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SC-51322 is a potent and selective antagonist of prostaglandin E2 (PGE2) receptor (EP 1), with a pA2 of 8.1. SC-51322 has the pain-relieving effect [1].
Cat. No.: HY-12182
CAS No.: 216158-34-8
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ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer [1].
Cat. No.: HY-106054
CAS No.: 79360-43-3
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Nocloprost, a prostaglandin E2 (PGE2) analog, is an orally active EP1- and EP3-receptor agonist. Nocloprost inhibits evoked [ 3H]ACh release. Nocloprost has gastroprotective and ulcer-healing properties. Nocloprost accelerates the healing of chronic gastric ulcerations and enhances mucosal growth in rats [1] .
Cat. No.: HY-120973
CAS No.: 215168-33-5
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EP1-antagonist-1 (Compound 27) is an EP1 antagonist with a pKi (FLIPR) of 9.31 and a pIC50 (binding) of 9.88. EP1-antagonist-1 can be used for the study of PGE2-mediated pain [1].
Cat. No.: HY-111304
CAS No.: 848188-18-1
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MF266-1 is a selective E prostanoid receptor 1 (EP1) antagonist with an Ki value of 3.8 nM. MF266-1 also has moderate selectivity for thromboxane A2 receptor (TP). MF266-1 is promising for research of arthritis [1].
Cat. No.: HY-110198
CAS No.: 459841-96-4
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ONO-8130 is an orally active and selective prostanoid EP1 receptor antagonist. ONO-8130 blocks phosphorylation of ERK in the L6 spinal cord. ONO-8130 relieves bladder pain in mice with cyclophosphamide-induced cystitis. ONO-8130 can be used for interstitial cystitis research [1].
Cat. No.: HY-127162
CAS No.: 69413-73-6
Synonyms: PGK1
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Prostaglandin K1 (compound 46) is a structurally modified analog of prostacyclin (prostanoid) with an EC50 of 2800 nM for EP1 and a Ki of 2800 nM [1].
Cat. No.: HY-121594
CAS No.: 892664-17-4
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GSK-269984B is a potent EP1 antagonist. GSK-269984B has the potential for inflammatory pain research [1].
Cat. No.: HY-111258
CAS No.: 869499-38-7
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GSK345931A is an EP1 receptor antagonist. GSK345931A shows measurable CNS penetration in the mouse and rat and potent analgesic efficacy in acute and sub-chronic models of inflammatory pain [1].
Cat. No.: HY-137574
CAS No.: 64625-55-4
Synonyms: 19(R)-Hydroxy PGE1
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19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations [1] .
Cat. No.: HY-138868
CAS No.: 1219032-20-8
Synonyms: 17-Phenyl trinor PGE2 ethyl amide
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17-Phenyl trinor prostaglandin E2 ethyl amide (17-Phenyl trinor PGE2 ethyl amide) is a EP1 receptor agonist. 17-Phenyl trinor prostaglandin E2 ethyl amide aggravates renal dysfunction and glomerulosclerosis [1].
Cat. No.: HY-B0131A
CAS No.: 27930-45-6
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Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.
Cat. No.: HY-14466
CAS No.: 612831-24-0
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GW 848687X is a selective, orally active prostaglandin EP1 receptor antagonist for the inhibition of inflammatory pain. The oral bioavailability of GW 848687X was 54% in rats and 53% in dogs. GW 848687X has a half-life of 2 hours and has inhibitory potential for both acute and chronic pain [1].
Cat. No.: HY-B0131S2
CAS No.: 2342573-59-3
Synonyms: Alprostadil-d9; PGE1-d9
Cat. No.: HY-10418R
CAS No.: 33458-93-4
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AH 6809 (Standard) is the analytical standard of AH 6809. This product is intended for research and analytical applications. AH 6809 is an antagonist of EP and DP receptor, with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively. AH 6809 has a Ki of 350 nM for mouse EP2 receptor [1] .
Cat. No.: HY-B0131S
CAS No.: 211105-33-8
Cat. No.: HY-W007888R
CAS No.: 698-27-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
