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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
129 Results for "
IGF1R
" in MedChemExpress (MCE) Product Catalog:
Products (129)
129 Results for "IGF1R" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-B0025
CAS No.: 83480-29-9
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1 Cited Publications
Cat. No.: HY-P99165
CAS No.: 1036734-93-6
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1
1 Cited Publications
Synonyms: ALK/IGF1R inhibitor
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AZD-3463 (ALK/IGF1R inhibitor) is an orally active ALK/IGF1R inhibitor, with a Ki of 0.75 nM for ALK. AZD3463 induces apoptosis and autophagy in neuroblastoma cells [1] .
1
1 Cited Publications
Cat. No.: HY-P99294
CAS No.: 905703-97-1
Synonyms: AMG 479; Human Anti-IGF1R Recombinant Antibody
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1
1 Cited Publications
Synonyms: I-OMe-AG 538
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I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells.?I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC50?of 1 μM [1].
1
Cat. No.: HY-P99197
CAS No.: 943453-46-1
Synonyms: CP-751871
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis [1].
Cat. No.: HY-P99672
CAS No.: 1509928-04-4
Synonyms: MM 141; MM-005
Cat. No.: HY-18785
CAS No.: 854171-35-0
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Indirubin Derivative E804 is a potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM for IGF1R.
Cat. No.: HY-P3226
CAS No.: 147819-32-7
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SU4312 is the racemate of (Z)-SU4312 and (E)-SU4312. (Z)-SU4312 inhibits PDGFR and FLK-1 with IC50s of 19.4 and 0.8 μM, respectively. (E)-SU4312 inhibits PDGFR, FLK-1, EGFR, HER-2, and IGF-1R with IC50s of 24.2, 5.2, 18.5, 16.9 and 10.0 μM, respectively [1].
Cat. No.: HY-177760
CAS No.: 1252037-41-4
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PrCP-7414 is a prolyl carboxypeptidase (PRCP) inhibitor. PrCP-7414 blocks PRCP-mediated activation of the IGF1R/HER3 signaling pathway and subsequent AKT activation. PrCP-7414 exhibits pro-apoptotic, anti-tumor and synergistic cytotoxic activities, and inhibits the proliferation and survival of triple-negative breast cancer cells. PrCP-7414 can be used for the research of breast cancer [1] .
Cat. No.: HY-P990084
CAS No.: 2728655-31-8
Synonyms: AVE1642; VRDN-001
Research Areas:
Veligrotug (AVE1642) is a selective, fully human IGF-1R antagonist antibody with a Kd value of 0.55 nM for hIGF-1R. Veligrotug blocks the phosphorylation of downstream AKT. Veligrotug is applicable to research related to thyroid eye disease [1] .
Cat. No.: HY-P5438
Cat. No.: HY-21291
CAS No.: 186611-55-2
SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation [1].
Synonyms: AXL1717 (Standard); Picropodophyllotoxin (Standard); PPP (Standard)
Category:
Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
