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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1329 Results for "
PD
" in MedChemExpress (MCE) Product Catalog:
Products (1329)
1329 Results for "PD" in MCE Product Catalog:
34
34 Cited Publications
Referencia número: HY-19991
No. CAS: 1675201-83-8
Synonyms: PD-1/PD-L1 inhibitor 1
Target:
Áreas de investigación:
BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM) .
28
28 Cited Publications
Target:
Áreas de investigación:
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.
27
27 Cited Publications
Referencia número: HY-P99144
Target:
Áreas de investigación:
27
27 Cited Publications
Referencia número: HY-19745
No. CAS: 1675203-84-5
Target:
Áreas de investigación:
BMS-202 is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 has antitumor activity .
27
27 Cited Publications
Referencia número: HY-19745B
No. CAS: 2089334-95-0
Target:
Áreas de investigación:
BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC50 of 18 nM and a KD of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity .
24
24
24 Cited Publications
Referencia número: HY-P9903
No. CAS: 946414-94-4
Synonyms: BMS-936558; ONO-4538; MDX-1106
Target:
23
23 Cited Publications
PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src.
22
22 Cited Publications
Referencia número: HY-W010342
No. CAS: 329-89-5
Target:
Áreas de investigación:
6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP +-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .
22
RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α . RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity .
20
20 Cited Publications
Synonyms: CI-1011; PD-148515
Target:
Áreas de investigación:
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively . Avasimibe can be used for the research of prostate cancer .
20
20 Cited Publications
Referencia número: HY-P99145
Target:
Áreas de investigación:
20
20 Cited Publications
Referencia número: HY-76201
No. CAS: 149003-01-0
Synonyms: ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride
Target:
Áreas de investigación:
Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases .
19
19 Cited Publications
Referencia número: HY-B0502
No. CAS: 93106-60-6
Synonyms: BAY Vp 2674; PD160788
Target:
Áreas de investigación:
Enrofloxacin (BAY Vp 2674) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis.
19
19 Cited Publications
Referencia número: HY-B0502A
No. CAS: 93106-59-3
Synonyms: BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride
Target:
Áreas de investigación:
Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).
17
17 Cited Publications
Synonyms: eFT508
Target:
Áreas de investigación:
Tomivosertib (eFT508) is a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib (eFT508) treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines . Tomivosertib (eFT508) also dramatically downregulates PD-L1 protein abundance .
16
14
14 Cited Publications
Target:
Áreas de investigación:
PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective .
14
14 Cited Publications
Referencia número: HY-17355
No. CAS: 104632-25-9
Target:
Áreas de investigación:
Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) .
14
14 Cited Publications
Referencia número: HY-B0410
No. CAS: 104632-26-0
Target:
Áreas de investigación:
Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
