BMS-202 hydrochloride

Name: BMS-202 hydrochloride
Brand: MedChemExpress
SKU: HY-19745B
Rating: 5.0 (25 reviews)

Cat. No.: HY-19745B Purity: 98.02%: Data Sheet
COA

SDS
Handling Instructions
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BMS-202 hydrochloride is a potent and nonpeptidic PD-1/PD-L1 complex inhibitor with an IC₅₀ of 18 nM and a K_D of 8 μM. BMS-202 hydrochloride binds to PD-L1 and blocks human PD-1/PD-L1 interaction. BMS-202 hydrochloride has antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 2089334-95-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 25 publication(s) in Google Scholar

Other Forms of BMS-202 hydrochloride:

N-deacetylated BMS-202 In-stock
BMS-202 In-stock

25 Publications Citing Use of MCE BMS-202 hydrochloride

Cell Migration/Invasion Assay

Flow Cytometry

Cell Proliferation/Viability Assay

RT-PCR

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):2156-2169. [Abstract]; Effects of compounds WP0 and BMS-202 to induce T-cell-mediated tumor killing against HepG2 Cells.

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Apr;15(4):2156-2169. [Abstract]; PD-L1 protein level in HepG2 cells. Cells were pretreated with lysosome inhibitor BafA (100 nmol/L), BMS-202 (1 μmol/L), TJ12P1 (1 μmol/L), or proteasome inhibitor MG132 (100 nmol/L), followed by treatment with WP0 (1 μmol/L).

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 Sep;32(3):242. [Abstract]; BMS-202 (5 μM, 24 h) inhibits A375 cell migration and invasion.

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 Sep;32(3):242. [Abstract]; RT-qPCR analysis revealed an increase in the mRNA expression levels of the pro-apoptotic factor Bax and a decrease in the mRNA expression levels of the anti-apoptotic factor Bcl-2 treated with BMS-202 (5 μM, 24 h).

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomater Res. 2023 Nov 24;27(1):120. [Abstract]; Compared with the blank control group, the PCN-224/HP NPs, BMS-202, BMS@P/HP NPs, PCN-224/HP+L and BMS@P/HP+L groups all showed different degrees of tumor cell apoptosis.

: BMS-202 hydrochloride purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 Feb;83(1):176-183. [Abstract]; Cultured Lβt2 cells are treated with 25 μM BMS-202 and collected at 24 h. the p-p38 MAPK, p38 MAPK, p-JNK, JNK, p-ERK, ERK, and α-tubulin protein levels are detected by Western Blotting.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

455.98

Formula

C₂₅H₃₀ClN₃O₃

CAS No.

2089334-95-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (219.31 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1931 mL	10.9654 mL	21.9308 mL
5 mM	0.4386 mL	2.1931 mL	4.3862 mL
10 mM	0.2193 mL	1.0965 mL	2.1931 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.02%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (243 KB) HNMR (263 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Zak KM, et al. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1). Oncotarget. 2016 May 24;7(21):30323-35. [Content Brief]

[2]. Ashizawa T, et al. Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse. Biomed Res. 2019;40(6):243-250. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.1931 mL	10.9654 mL	21.9308 mL	54.8270 mL
	5 mM	0.4386 mL	2.1931 mL	4.3862 mL	10.9654 mL
	10 mM	0.2193 mL	1.0965 mL	2.1931 mL	5.4827 mL
	15 mM	0.1462 mL	0.7310 mL	1.4621 mL	3.6551 mL
	20 mM	0.1097 mL	0.5483 mL	1.0965 mL	2.7413 mL
	25 mM	0.0877 mL	0.4386 mL	0.8772 mL	2.1931 mL
	30 mM	0.0731 mL	0.3655 mL	0.7310 mL	1.8276 mL
	40 mM	0.0548 mL	0.2741 mL	0.5483 mL	1.3707 mL
	50 mM	0.0439 mL	0.2193 mL	0.4386 mL	1.0965 mL
	60 mM	0.0366 mL	0.1828 mL	0.3655 mL	0.9138 mL
	80 mM	0.0274 mL	0.1371 mL	0.2741 mL	0.6853 mL
	100 mM	0.0219 mL	0.1097 mL	0.2193 mL	0.5483 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.