881 Results for "

Targeted peptides

" in MedChemExpress (MCE) Product Catalog:
Products (881)

881 Results for "Targeted peptides" in MCE Product Catalog:

2
Gramicidin S
Gramicidin S
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2 Cited Publications
Art. -Nr.: HY-P5712
CAS. Nr.: 113-73-5
Synonyms: Gramicidin soviet
Target:  

Antibiotic Bacterial Na+/K+ ATPase

Forschungsgebiete:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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T9 peptide
T9 peptide
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1 Cited Publications
Art. -Nr.: HY-P10645
CAS. Nr.: 1098005-45-8
Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Cardiovascular Disease

T9 peptide (SKTFNTHPQSTP) is a muscle targeting peptide. T9 peptide binds strongly to C2C12 myoblasts. T9 peptide is capable of increased specificity for the heart and quadriceps muscles if conjugated to oligonucleotides without a similar effect in targeting to the kidney, liver, and diaphragm.
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PSMA targeting peptide TFA
PSMA targeting peptide TFA
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1 Cited Publications
Art. -Nr.: HY-P10055A
Synonyms: PSMA-1 TFA
Target:  

PSMA

Forschungsgebiete:  

Cancer

PSMA targeting peptide TFA (PSMA-1 TFA) is a PSMA targeting peptide (GRFLTGGTGRLLRIS) and can be used for targeted delivery of glucose-regulated protein (GRP)-silencing siRNAs in PCa cells .
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1
CCP peptide TFA
CCP peptide TFA
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1 Cited Publications
Art. -Nr.: HY-P2171A
Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Inflammation/Immunology

CCP peptide TFA is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide TFA functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA) .
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1
SP94 peptide, Cys conjugated
SP94 peptide, Cys conjugated
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1 Cited Publications
Art. -Nr.: HY-P11050
CAS. Nr.: 1309883-67-7
Target:  

Inhibitory Antibodies

Forschungsgebiete:  

Cancer

SP94 peptide, Cys conjugated is a hepatocellular carcinoma (HCC)-targeting peptide conjugated with Cys. SP94 peptide, Cys conjugated can be used for synthesis of stimuli-responsive peptide nanomaterials (SRPNs) like platinum nanocluster assemblies (PT-NA) and it promotes the entry of PT-NA into HCC cells by mediating endocytosis. SP94 peptide, Cys conjugated can be used for cancers research .
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1
Fmoc-His(Trt)-OH
Fmoc-His(Trt)-OH
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1 Cited Publications
Art. -Nr.: HY-W010712
CAS. Nr.: 109425-51-6
Target:  

Amino Acid Derivatives

Forschungsgebiete:  

Others

Fmoc-His(Trt)-OH is a histidine derivative with a trityl (Trt) group protecting the His side chain. Fmoc-His(Trt)-OH also has an Fmoc group protecting the α-NH2 group. Fmoc-His(Trt)-OH can be used in solid-phase peptide synthesis to prevent racemization and byproduct formation. Fmoc-His(Trt)-OH acts as a protected histidine precursor in solid-phase peptide synthesis (SPPS), participating in peptide chain construction through amide bond formation. Fmoc-His(Trt)-OH can be precisely incorporated into the target peptide sequence, ensuring correct peptide chain synthesis and reducing impurity formation. Fmoc-His(Trt)-OH is mainly used in the solid-phase synthesis research of pharmaceutical peptides and bioactive peptides, and is particularly suitable for the preparation of peptide drugs requiring precise control of histidine configuration .
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1
DPI-4452
DPI-4452
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1 Cited Publications
Art. -Nr.: HY-P10761
CAS. Nr.: 2941391-49-5
Target:  

Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase

Forschungsgebiete:  

Cancer

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC50 for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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1
TAT-14
TAT-14
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1 Cited Publications
Art. -Nr.: HY-P1328
CAS. Nr.: 1362661-34-4
Target:  

Keap1-Nrf2

Forschungsgebiete:  

Others

TAT-14 is a 14-mer peptide that acts as Nrf2 activator with an anti-inflammatory effect. TAT-14 has no effect on Nrf2 mRNA expression, but increases Nrf2 protein level due to targeting the Nrf2 binding site on Keap1 .
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RVG
RVG
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1 Cited Publications
Art. -Nr.: HY-P5623
CAS. Nr.: 115136-25-9
Synonyms: RVG29; RDP; Rabies Virus Glycoprotein-29
Target:  

nAChR Interleukin Related

Forschungsgebiete:  

Neurological Disease Inflammation/Immunology

RVG (RVG29) is a blood-brain barrier-permeable peptide derived from rabies virus glycoprotein, which binds to the α-7 subunit of neuronal nicotinic acetylcholine receptor (AchR). RVG efficiently delivers drugs to nerve cells and antigen-presenting cells in a targeted manner, and enhances the efficiency of antigen presentation and drug delivery .
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Inclacumab
Inclacumab
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1 Cited Publications
Art. -Nr.: HY-P99263
CAS. Nr.: 1256258-86-2
Synonyms: Anti-Human selectin P Recombinant Antibody

Target:  

P-selectin

Forschungsgebiete:  

Cardiovascular Disease

Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion .
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1
SPL-707
SPL-707
0 Images
1 Cited Publications
Art. -Nr.: HY-111360
CAS. Nr.: 2195361-33-0
Reinheit:  99.94%
Target:  

γ-secretase

Forschungsgebiete:  

Inflammation/Immunology

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells .
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Trimethyl chitosan
Trimethyl chitosan
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1 Cited Publications
Art. -Nr.: HY-148033
CAS. Nr.: 52349-26-5
Synonyms: N,N,N-Trimethylchitosan
Trimethyl chitosan (N,N,N-Trimethylchitosan) is a multifunctional polymer and a derivative of Chitosan (HY-B2144A). Trimethyl chitosan targets the absorption enhancing proteins of tight junctions of intestinal and mucosal epithelial cells, induces tight junction protein rearrangement, and increases intercellular permeability. Trimethyl chitosan can stimulate the activity of promoting transmembrane transport of hydrophilic drugs (such as peptides and proteins) and can be used for drug delivery and synthesis of nanoparticles .
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Cyclic GMP
Cyclic GMP
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1 Cited Publications
Art. -Nr.: HY-113469
CAS. Nr.: 7665-99-8
Reinheit:  99.43%
Category:  

Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite

Target:  

Endogenous Metabolite

Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .
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Cyclic GMP sodium
Cyclic GMP sodium
0 Images
1 Cited Publications
Art. -Nr.: HY-113469A
CAS. Nr.: 40732-48-7
Reinheit:  99.89%
Category:  

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .
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CREKA peptide
CREKA peptide
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Art. -Nr.: HY-P10709
CAS. Nr.: 847058-45-1
Target:  

Collagen

Forschungsgebiete:  

Cardiovascular Disease Cancer

CREKA peptide is a selective non-covalent binding agent targeting fibrin, type IV collagen, and fibronectin, often used as a targeting ligand to modify delivery carriers. CREKA peptide specifically recognizes fibrin, fibronectin, and type IV collagen that are excessively deposited in the tumor microenvironment or fibrotic tissue, mediating the targeted accumulation of the carrier at the lesion site and promoting drug internalization into target cells (such as cancer cells and activated hepatic stellate cells). CREKA peptide can enhance targeted delivery efficiency, increase drug concentration at the lesion site, and reduce systemic side effects .
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Kidney-targeting peptide
Kidney-targeting peptide
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Art. -Nr.: HY-P11069
CAS. Nr.: 3106628-25-2
Target:  

Biochemical Assay Reagents

Forschungsgebiete:  

Metabolic Disease

Kidney-targeting peptide is a kidney-targeting peptide (KTP). Kidney-targeting peptide significantly enhances the renal targeting ability of Isoquercitrin (HY-N1445). Kidney-targeting peptide can be used in diabetic nephropathy research .
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DOTA-GPC3 targeting peptide 2
DOTA-GPC3 targeting peptide 2
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Art. -Nr.: HY-W1124925
CAS. Nr.: 3066439-94-6
Target:  

Radionuclide-Drug Conjugates (RDCs) Glycoprotein VI

Forschungsgebiete:  

Cancer

DOTA-GPC3 targeting peptide 2 (Sequence 30) is a RDC peptide targeting GPC3, with Kd of 0.3 nM. DOTA-GPC3 targeting peptide 2 is composed of DOTA and GPC3 targeting peptide 2. DOTA-GPC3 targeting peptide 2 can be labeled with radioactive elements .
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DSPE-PEG2000-APWHLSSQYSRT
DSPE-PEG2000-APWHLSSQYSRT
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Art. -Nr.: HY-177203
Target:  

Liposome

Forschungsgebiete:  

Cardiovascular Disease

DSPE-PEG2000-APWHLSSQYSRT is a PEG compound which composed of DSPE and 12-amino acid cardiac targeting peptide (APWHLSSQYSRT). DSPE-PEG2000-APWHLSSQYSRT can be used for drug delivery .
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GPC3 targeting peptide 1 TFA
GPC3 targeting peptide 1 TFA
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Art. -Nr.: HY-P10888A
Target:  

Glycoprotein VI

Forschungsgebiete:  

Cancer

GPC3 targeting peptide 1 TFA is a GPC3 targeting peptide, with a Kd value of 0.23 nM .
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tLyP-1 peptide
tLyP-1 peptide
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Art. -Nr.: HY-P10787
CAS. Nr.: 1354801-55-0
Target:  

Complement System

Forschungsgebiete:  

Cancer

tLyP-1 peptide is an NRP-1 targeting peptide with an IC50 of 4 μM, and its amino acid sequence is CGNKRTR. tLyP-1 peptide specifically binds to NRP-1 to target tumor cells .
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Assay Types