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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
polyamine
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "polyamine" in MCE Product Catalog:
Synonyms: Monoacetylcadaverine
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Cat. No.: HY-16395
CAS No.: 308145-19-9
Synonyms: CGC-11047
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PG-11047 (CGC-11047) is a polyamine analogue. PG-11047 can be used for the research of breast cancer .
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Synonyms: SBP-101
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Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers .
Synonyms: 5-FMOrn dihydrochloride
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5-Fluoromethylornithine dihydrochloride (5-FMOrn dihydrochloride) is an orally active and blood-brain barrier-penetrant irreversible inhibitor of ornithine aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride competes with ornithine at the OAT active site and acts as a poor substrate for ornithine decarboxylase (ODC), competitively reducing ornithine decarboxylation, elevating tissue ornithine, and thereby affecting polyamine metabolism . 5-Fluoromethylornithine dihydrochloride attenuates Thioacetamide (HY-Y0698)-induced acute liver injury-related pathological changes . 5-Fluoromethylornithine dihydrochloride is used in research on acute liver injury and hyperammonemia .
Cat. No.: HY-160791
CAS No.: 1430194-56-1
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Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .
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JNJ-1289 is a potent, selective, competitive and allosteric human spermine oxidase (hSMOX) inhibitor (IC50: 50 nM). JNJ-1289 can be used in the research of polyamine catabolism, inflammation and cancers .
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F-14512 is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 can be used to study breast cancer .
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Diamine oxidase (DAO) is an orally active enzyme. Diamine oxidase catalyzes oxidative deamination of various polyamines. Diamine oxidase degrades histamine and polyamines to maintain the metabolic balance of amines in the body. Diamine oxidase is a key regulatory enzyme in rapidly proliferating tissues such as bone marrow and intestinal mucosa. Diamine oxidase can be used in research related to intestinal diseases, small bowel transplant rejection, histamine intolerance, and other conditions .
Cat. No.: HY-16394
CAS No.: 206991-64-2
Synonyms: CGC-11047 tetrahydrochloride
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PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities .
Cat. No.: HY-D1478
CAS No.: 2678634-03-0
Cat. No.: HY-160791A
CAS No.: 3030428-57-7
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Claramine TFA is a steroidal polyamine. Claramine TFA can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins .
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Cat. No.: HY-W654139
CAS No.: 2699607-01-5
Cat. No.: HY-160791B
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Claramine hydrochloride is a steroid polyamine with blood-brain barrier permeability. Claramine hydrochloride can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins .
Cat. No.: HY-151884
CAS No.: 1242862-71-0
FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines .
Synonyms: DEHSPM
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Diethylhomospermine is a polyamine analogue. Diethylhomospermine has antitumor and antidiarrheal activity .
Cat. No.: HY-W099540
CAS No.: 5538-95-4
OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
