Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5471 Results for "
BALB-Rag/γC mice
" in MedChemExpress (MCE) Product Catalog:
Products (5471)
5471 Results for "BALB-Rag/γC mice" in MCE Product Catalog:
Cat. No.: HY-185561
Synonyms: RC88
Target:
Research Areas:
Misitatug blivedotin (RC88) is an antibody-drug conjugate (ADC) targeting mesothelin (MSLN). Misitatug blivedotin binds to mesothelin and exhibits dose‐dependent antitumor activity. Misitatug blivedotin can be used for the research of ovarian cancer, non-squamous non-small-cell lung carcinoma, cervical cancer .
Cat. No.: HY-186112
CAS No.: 88134-39-8
Target:
Research Areas:
PSFL2915 is a selective, orally active P2X receptor inhibitor with oral effectiveness, with an IC50 of 0.319 μM for human P2X3, 0.261 μM for rat P2X2/3, and 13.3 μM for human P2X2. PSFL2915 exhibits ~42-fold selectivity over human P2X2. PSFL2915 can be used for the research of chronic cough .
Cat. No.: HY-187678
CAS No.: 3024011-79-5
Research Areas:
NCGC-023 is a LATS1/2 inhibitor. NCGC-023 selectively inhibits LATS1/2, an upstream regulator of Yap in the Hippo signaling pathway, increases the expression of active Yap protein, activates Yap-dependent signaling pathways, triggers non-Yap-dependent metallothionein-mediated heavy metal responses, and upregulates IL-33-related regenerative responses. NCGC-023 can be used in studies related to gastrointestinal acute radiation syndrome (GI-ARS) .
Cat. No.: HY-187719
CAS No.: 318262-42-9
Target:
Research Areas:
NIK-12192 is an orally active inhibitor of vacuolar H +-ATPase. NIK-12192 reduces intracellular pH, decreases lysosomal volume and acidity, and alters the intracellular localization of V-ATPase by inhibiting proton pumps . NIK-12192 induces αvβ5 integrin polarization, cytoskeletal disruption, cell detachment, anoikis-mediated delayed apoptosis and necrosis, a delayed reduction in mitochondrial membrane potential, and lysosomal/phagosomal accumulation. NIK-12192 inhibits tumor cell migration, invasion, and three-dimensional spheroid growth, and enhances the activity of Topotecan (HY-13768). NIK-12192 suppresses spontaneous lung metastasis in vivo. NIK-12192 is used in research related to colon cancer, ovarian cancer, lung cancer, breast cancer, renal cancer, prostate cancer, acute myeloid leukemia, and melanoma .
Cat. No.: HY-187914
CAS No.: 2245791-50-6
OTB-658 is a conformationally restricted oxazolidinone antibacterial candidate that exhibits bacteriostatic activity against Mycobacterium tuberculosis. OTB-658 enters macrophages and inhibits intracellular M. tuberculosis growth. OTB-658 exhibits dose-dependent antibacterial activity. OTB-658 is used in research related to tuberculosis and drug-resistant tuberculosis .
Cat. No.: HY-D3235
CAS No.: 2540586-21-6
Cat. No.: HY-DY2024
Target:
Research Areas:
0.5% Evans Blue Staining Solution is an azo dye solution that strongly binds to serum albumin to form a high-molecular-weight tracer complex. 0.5% Evans Blue Staining Solution can passively leak with albumin and produce color when the blood-brain barrier or vascular barrier is damaged in vivo, and it is used for permeability assessment. 0.5% Evans Blue Staining Solution is excluded by living cells but enters dead cells to stain them in vitro due to the loss of membrane integrity in dead cells. 0.5% Evans Blue Staining Solution can be used for studies related to the identification of dead/necrotic cells and blood-brain barrier (BBB) permeability .
Cat. No.: HY-N16792
CAS No.: 202526-51-0
Category:
Target:
Cat. No.: HY-N17685
CAS No.: 98474-77-2
Target:
Cat. No.: HY-N21846
CAS No.: 82516-67-4
Category:
Target:
Cat. No.: HY-N6043
CAS No.: 69039-02-7
Cat. No.: HY-P11931
NODA-FGLP21 is a tumor-targeting agent and a fibrinogen-like protein 1 (FGL1) binder. NODA-FGLP21 specifically binds to FGL1, and this binding is competitively inhibited by unlabeled FGLP21. NODA-FGLP21 can be used in the research of liver cancer .
Target:
Research Areas:
Pyruvate carboxylase is a key mitochondrial anaplerotic enzyme that catalyzes the conversion of pyruvate to oxaloacetate. Pyruvate carboxylase not only maintains tricarboxylic acid cycle activity and redox homeostasis, but also drives hepatic gluconeogenesis and fatty acid synthesis. The activity of Pyruvate carboxylase is upregulated in insulin-resistant states, exacerbating hepatic glucose production. Pyruvate carboxylase also shows significantly enhanced expression in early-stage non-small cell lung cancer (NSCLC). Pyruvate carboxylase promotes tumor proliferation by supporting nucleotide and lipid synthesis, and its functional deficiency cannot be compensated by glutaminolysis. Pyruvate carboxylase can be used in the research of prediabetes type 2 and NSCLC .
Cat. No.: HY-P4610
CAS No.: 19653-76-0
Target:
Research Areas:
Cat. No.: HY-P990060
CAS No.: 2488745-86-2
Synonyms: Mim8
Target:
Research Areas:
Cat. No.: HY-P990980
CAS No.: 2919209-65-5
Synonyms: CND-106; EMB-06
Target:
Research Areas:
Cizutamig (CND-106) is a bispecific T-cell engager targeting BCMA and CD3. Cizutamig exhibits immunostimulatory and anti-tumor activities. Cizutamig can be used in research related to relapsed or refractory multiple myeloma and systemic lupus erythematosus .
Cat. No.: HY-P991900
Target:
Research Areas:
Cat. No.: HY-W008385
CAS No.: 156-86-5
Synonyms: L-Homoarginine
Cat. No.: HY-W008385AS
Synonyms: L-Homoarginine-d4 dihydrochloride
H-HoArg-OH-d4 dihydrochloride (L-Homoarginine-d4 dihydrochloride) is the d4-labeled H-HoArg-OH dihydrochloride. H-HoArg-OH dihydrochloride (L-Homoarginine dihydrochloride) is an orally active endogenous non-protein amino acid. H-HoArg-OH dihydrochloride acts as a weak alternative substrate for NOS and interferes with NO production, selectively inhibits tissue-nonspecific alkaline phosphatase (TNAP), and suppresses the uptake of arginine by y +-type transporters (system y +). H-HoArg-OH dihydrochloride increases tissue hArg concentrations in vivo, regulates amino acid homeostasis, and improves renal function and pathological features of diabetic nephropathy. H-HoArg-OH dihydrochloride can be used in studies related to diabetes and cardiomyopathy .
Cat. No.: HY-W008385R
CAS No.: 156-86-5
Synonyms: L-Homoarginine (Standard)
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
