Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
58 Results for "
KDM5
" in MedChemExpress (MCE) Product Catalog:
Products (58)
58 Results for "KDM5" in MCE Product Catalog:
Cat. No.: HY-100421R
CAS No.: 1628208-23-0
Research Areas:
CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .
Cat. No.: HY-125243
CAS No.: 2281766-67-2
Target:
Research Areas:
KDM5A-IN-2 is a KDM5A inhibitor. The human IC50 values of KDM5A-IN-2 for KDM5A, KDM5B, and KDM4A are 0.11 μM, 0.22 μM, and 5.3 μM, respectively. KDM5A-IN-2 inhibits KDM5B- and KDM4A-mediated histone lysine demethylation .
Cat. No.: HY-104048R
CAS No.: 1851373-36-8
Research Areas:
QC6352 (Standard) is the analytical standard of QC6352 (HY-104048). This product is intended for research and analytical applications. QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B) .
Cat. No.: HY-RS16636
Target:
Research Areas:
Kdm5b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm5b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17171
Target:
Research Areas:
Kdm5d Mouse Pre-designed siRNA Set A contains three designed siRNAs for Kdm5d gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23299
Target:
Research Areas:
Kdm5c Rat Pre-designed siRNA Set A contains three designed siRNAs for Kdm5c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-136682
CAS No.: 1613410-75-5
Target:
Research Areas:
N19-0881 (Compound 33) is an orally active, potent and selective KDM5A/5B histone lysine demethylase inhibitor (IC50= 0.013 μM and 0.002 μM, respectively). N19-0881 is promising for research of epigenetically dysregulated tumors (e.g., breast cancer) .
Cat. No.: HY-100764R
CAS No.: 708991-09-7
Research Areas:
YUKA1 (Standard) is the analytical standard of YUKA1 (HY-100764). This product is intended for research and analytical applications. YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM. YUKA1 has less inhibitory active on KDM5C (IC50 = 7.12 μM) and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 can increase H3K4me3 levels and inhibit cell proliferation. YUKA1 can be used for the research of cancer, such as lung and breast cancers .
Cat. No.: HY-100744R
CAS No.: 796-42-9
Synonyms: NSC51355 (Standard)
Research Areas:
AS8351 (Standard) is the analytical standard of AS8351 (HY-100744). This product is intended for research and analytical applications. AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells .
Cat. No.: HY-183618
Target:
Research Areas:
DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs). DW-229 degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells. DW-229 shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer .
Cat. No.: HY-P702875
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT Rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P85482
Synonyms: DXS1272E; Histone demethylase JARID1C; JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji, AT rich interactive domain 1C; RBP2 like; Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; Lysine; K; specific demethylase 5C; Lysine-specific demethylase 5C; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; SMCX; Smcx homolog X chromosome; SmcX protein; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein; Xe169 protein.
Cat. No.: HY-P703589
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: KDM5A; Histone Demethylase JARID1A; Prev. RBBP2; RBP2; Prev. JARID1A; Jumonji, AT Rich Interactive Domain 1A (RBBP2-Like); Lysine-Specific Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5A; Jumonji, AT Rich Interactive Domain 1A; Jumonji/ARID Domain-Containing Protein 1A; Retinoblastoma Binding Protein 2; Lysine (K)-Specific Demethylase 5A; NEDEHC; Retinoblastoma-Binding Protein 2; Lysine Demethylase 5A; RBBP-2
Species:
Human
Source:
E. coli
Cat. No.: HY-P702902
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: KDM5C; Protein SmcX; Prev. JARID1C; Jumonji, AT Rich Interactive Domain 1C; Prev. SMCX; JmjC Domain-Containing Protein SMCX; Prev. MRX13; Mental Retardation, X-Linked 13; DXS1272E; Smcy Homolog, X-Linked (Mouse); XE169; Smcx Homolog, X Chromosome; [Histon
Species:
Human
Source:
Sf9 insect cells
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
