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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
irritable
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "irritable" in MCE Product Catalog:
Cat. No.: HY-105108
CAS No.: 209859-87-0
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Cilansetron hydrochloride hydrate is a 5-HT3 receptor antagonist. Cilansetron hydrochloride hydrate can be used in studies of irritable bowel syndrome .
Cat. No.: HY-167687
CAS No.: 1184662-02-9
Synonyms: (RS)-DSP-6952 free base
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(RS)-Minesapride is a serotonin receptor agonist, exhibiting potential therapeutic activity for patients with irritable bowel syndrome with predominant constipation (IBS-C).
Cat. No.: HY-105109B
CAS No.: 120635-77-0
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(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome .
Cat. No.: HY-19456
CAS No.: 1239279-30-1
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SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS) .
Cat. No.: HY-103403
CAS No.: 156907-84-5
Synonyms: PNU96391 hydrochloride
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(-)-OSU6162 (PNU96391) hydrochloride is a dopamine stabilizer. (-)-OSU6162 hydrochloride acts as partial agonist at 5-HT2A and is a dopamine D2 antagonist. (-)-OSU6162 hydrochloride can be used for the research of aggression and irritability .
Cat. No.: HY-105534
CAS No.: 217185-75-6
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TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome .
Cat. No.: HY-116755
CAS No.: 55837-29-1
Synonyms: CR 605
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Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia .
Cat. No.: HY-167639
CAS No.: 132036-90-9
Synonyms: (S)-YM060 free base
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(S)-Ramosetron ((S)-YM060 free base) is an orally active antagonist of the 5-hydroxytryptamine 5-HT3 receptor. (S)-Ramosetron is promising for research of diseases related to nausea and vomiting, irritable bowel syndrome (IBS) .
Cat. No.: HY-P5782
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Cat. No.: HY-19436A
CAS No.: 451470-34-1
Synonyms: GW 427353B
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Solabegron hydrochloride is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM . Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .
Cat. No.: HY-147564
CAS No.: 2759292-94-7
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RET-IN-18 is a pyridone compound. is a potent inhibitor of RET. RET-IN-18 is a potent inhibitor of RET. RET-IN-18 has the potential for the research of diseases related to irritable bowel syndrome (IBS) and other gastrointestinal disorders, as well as cancers, and neurodegenerative diseases (extracted from patent WO2022017524A1, compound 1) .
Cat. No.: HY-14147A
Purity: 98.06%
Synonyms: (S)-BRL 24924
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(S)-Renzapride ((S)-BRL 24924) is the isomer of HY-14147 Renzapride. Renzapride is a 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride also is a 5HT2b and 5HT3 receptor antagonist. Renzapride can be used for constipation predominant irritable bowel syndrome (C-IBS) study .
Cat. No.: HY-10049
CAS No.: 145742-28-5
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CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg). CP 122721 inhibits kainate (KA)-induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS) .
Cat. No.: HY-101225
CAS No.: 1451210-48-2
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8 Hydroxy PIPAT oxalate is a 5-HT1A receptor agonist that promotes histamine release. 8 Hydroxy PIPAT oxalate selectively activates 5-HT1A receptors, thereby triggering mast cell degranulation and histamine release. 8 Hydroxy PIPAT oxalate is applicable to research related to irritable bowel syndrome .
Cat. No.: HY-106982
CAS No.: 147116-64-1
Synonyms: CJ-11,974
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Ezlopitant (CJ-11,974) is a selective, non-peptidic neurokinin-1 (NK-1)-receptor antagonist. Ezlopitant inhibits both acute and delayed emetic reactions induced by Cisplatin (HY-17394) in ferrets via acting on NK1 receptors in the central nervous system. Ezlopitant has the potential for pain, chemotherapy-induced emesis and irritable bowel syndrome research .
Cat. No.: HY-14148
CAS No.: 109872-41-5
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Renzapride hydrochloride is a benzamide that inhibits irritable bowel syndrome and has antagonistic activity at 5-HT(3) receptors and agonistic activity at 5-HT(4) receptors. Renzapride hydrochloride also exhibits antagonistic activity at 5-HT(2B) receptors and has a certain affinity for 5-HT(2A) and 5-HT(2C) receptors .
Cat. No.: HY-103377R
CAS No.: 220953-69-5
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Antalarmin (hydrochloride) (Standard) is the analytical standard of Antalarmin (hydrochloride). This product is intended for research and analytical applications. Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome .
Cat. No.: HY-19436S
CAS No.: 1250988-09-0
Synonyms: GW 427353-d8
Cat. No.: HY-12140
CAS No.: 334476-46-9
Synonyms: GW597599
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Vestipitant (GW597599) is a neurokinin-1 receptor antagonist (pKi: 9.4, hNK1) with hypnotic effects and the ability to suppress primary insomnia. Vestipitant can effectively block substance P-mediated extracellular regulated kinase phosphorylation and relieve anxiety and possible depression induced by the agonist GR73632 (HY-P1192) in gerbils. Vestipitant can also improve functional dyspnea, anxiety, insomnia, irritable bowel disease, gastroesophageal reflux disease, tinnitus and antiemetic effects .
Cat. No.: HY-70050CR
CAS No.: 122852-69-1
Synonyms: GR 68755C (Standard); GR 68755 Hydrochloride (Standard); GR 68755X Hydrochloride (Standard)
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Alosetron (Hydrochloride) (Standard) is the analytical standard of Alosetron (Hydrochloride). This product is intended for research and analytical applications. Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
