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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
79 Results for "
irritable
" in MedChemExpress (MCE) Product Catalog:
Products (79)
79 Results for "irritable" in MCE Product Catalog:
Cat. No.: HY-70050
CAS No.: 132414-02-9
Synonyms: GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X))
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Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .
Cat. No.: HY-70050B
CAS No.: 122852-43-1
Synonyms: GR 68755 ((Z)-2-butenedioate); GR 68755X ((Z)-2-butenedioate)
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Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Z)-2-butenedioate is used for the research of irritable bowel syndrome (IBS). Alosetron (Z)-2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron (Z)-2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .
Cat. No.: HY-109065
CAS No.: 1184662-54-1
Synonyms: DSP-6952 free base
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Minesapride (DSP-6952 free base) is an orally active, selective 5-HT4 receptor partial agonist. Minesapride enhances gastrointestinal motility, colonic transit and defecation function, and inhibits visceral hypersensitivity. Minesapride does not inhibit/induce cytochrome P450 isozymes, has no significant affinity for hERG, and does not trigger the risk of cardiac ischemia via coronary vasoconstriction. Minesapride can be used in research related to constipation-predominant irritable bowel syndrome, chronic constipation, atonic constipation, spastic constipation, functional constipation and functional dyspepsia .
Cat. No.: HY-19927A
CAS No.: 1645260-76-9
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DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist. DA-6886 induces relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels reveals that it inhibits hERG channel current with an pIC50 value of 4.3, indicating that the compound is 1000-fold more selective for the 5-HT4 receptor over hERG channels. DA-6886 can be used in the study of constipated irritable bowel syndrome .
Cat. No.: HY-101324AR
CAS No.: 61655-58-1
Synonyms: CPP monohydrochloride (Standard)
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MK-212 (monohydrochloride) (Standard) is the analytical standard of MK-212 (monohydrochloride). This product is intended for research and analytical applications. MK-212 monohydrochloride (CPP monohydrochloride) is an orally active, blood-brain barrier permeable agonist of 5-HT1C, 5-HT2 and 5-HT1A receptors. MK-212 monohydrochloride induces hyperthermia, nausea, arousal, irritability and restlessness, inhibits the elevation of plasma cortisol and prolactin, and reduces feelings of calmness and overall positive affect. MK-212 monohydrochloride mediates anxiety-like behaviors and motor inhibition. MK-212 monohydrochloride is applicable to research related to schizophrenia and anxiety disorders .
Cat. No.: HY-14153S
CAS No.: 1134188-56-9
Cat. No.: HY-B0380S2
Cat. No.: HY-15026
CAS No.: 915798-75-3
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ATB-429, a novel H2S-releasing derivative of mesalamine, demonstrates significant anti-nociceptive and anti-inflammatory effects in models of irritable bowel syndrome (IBS). By releasing hydrogen sulfide (H2S), ATB-429 modulates colorectal distension-induced hypersensitivity in both healthy and postcolitic rats. It attenuates abdominal withdrawal responses and suppresses spinal c-Fos mRNA expression, indicating its potential to alleviate pain associated with gastrointestinal inflammation. Moreover, ATB-429 down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA expression, effects not observed with mesalamine alone. The mechanism involves ATP-sensitive K+ (KATP) channels, as evidenced by reversal of ATB-429's effects with glibenclamide. These findings suggest ATB-429 could offer therapeutic benefits for managing painful intestinal disorders linked to inflammation .
Cat. No.: HY-B0380R
CAS No.: 39133-31-8
Target:
Opioid Receptor Toll-like Receptor (TLR) Calcium Channel Potassium Channel IRAK ERK JNK NF-κB Akt Apoptosis Reference Standards
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Trimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca 2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS) .
Cat. No.: HY-43934
CAS No.: 53567-47-8
Synonyms: CR 605 hydrochloride
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Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia .
Cat. No.: HY-107649R
CAS No.: 127308-98-9
Synonyms: UK-76654 fumarate (Standard)
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Zamifenacin fumarate (Standard) is the analytical standard of Zamifenacin (fumarate) (HY-107649). This product is intended for research and analytical applications. Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome .
Cat. No.: HY-N16477
CAS No.: 88167-26-4
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Cat. No.: HY-101225A
CAS No.: 159651-91-9
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8 Hydroxy PIPAT is a 5-HT1A receptor agonist that promotes histamine release. 8 Hydroxy PIPAT selectively activates 5-HT1A receptors, thereby triggering mast cell degranulation and histamine release. 8 Hydroxy PIPAT is applicable to research related to irritable bowel syndrome .
Cat. No.: HY-116755S2
Synonyms: CR 605-d5 oxalate
Cat. No.: HY-100459R
CAS No.: 1627856-64-7
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GSK3179106 (Standard) is the analytical standard of GSK3179106 (HY-100459). This product is intended for research and analytical applications. GSK3179106 is an orally active and selective RET kinase inhibitor with IC50s of 0.4 nM, 0.2 nM for human RET and rat RET, respectively. GSK3179106 has the potential for irritable bowel syndrome (IBS) through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity .
Cat. No.: HY-N17727
CAS No.: 331433-08-0
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Cat. No.: HY-107384AR
CAS No.: 185951-07-9
Synonyms: EMD-61753 hydrochloride (Standard)
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Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Asimadoline hydrochloride (Standard) (EMD-61753 hydrochloride (Standard)) is the analytical standard of Asimadoline (hydrochloride) (HY-107384A). This product is intended for research and analytical applications. Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS) .
Cat. No.: HY-109065A
CAS No.: 1184661-33-3
Synonyms: DSP-6952 hydrobromide
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Minesapride hydrobromide (DSP-6952 hydrobromide) is an orally active, selective 5-HT4 receptor partial agonist. Minesapride hydrobromide enhances gastrointestinal motility, colonic transit and defecation function, and inhibits visceral hypersensitivity. Minesapride hydrobromide does not inhibit/induce cytochrome P450 isozymes, has no significant affinity for hERG, and does not trigger the risk of cardiac ischemia via coronary vasoconstriction. Minesapride hydrobromide can be used in research related to constipation-predominant irritable bowel syndrome, chronic constipation, atonic constipation, spastic constipation, functional constipation and functional dyspepsia .
Cat. No.: HY-111191R
CAS No.: 895169-20-7
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ONO-2952 (Standard) is the analytical standard of ONO-2952 (HY-111191). This product is intended for research and analytical applications. ONO-2952 is a potent, selective and orally active translocator protein 18 Kda (TSPO) antagonist with Ki of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
