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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
222 Results for "
depolarization
" in MedChemExpress (MCE) Product Catalog:
Products (222)
222 Results for "depolarization" in MCE Product Catalog:
Cat. No.: HY-P3889
CAS No.: 51165-07-2
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DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation .
Cat. No.: HY-127149
CAS No.: 125533-88-2
Synonyms: Ro 40-8757
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Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells .
Cat. No.: HY-175376
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QPyN16Th is an N-palmitoylated cationic thiazolidine antibiotic. QPyN16Th is selectively active against the Gram-positive bavteria E. faecalis, S. aureus and MRSA with an MIC of 1.95 μM over gram-negative bacteria. QPyN16Th can induce membrane permeabilization and depolarization and ROS production in MRSA. QPyN16Th increases the survival of zebrafish model of intramuscular MRSA infection .
Cat. No.: HY-177763
CAS No.: 2791281-99-5
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TRPM8 receptor agonist-1 (Example 81) is a TRPM8 receptor agonist. TRPM8 receptor agonist-1 can trigger the inward flow of calcium, sodium and other ions within the cell, causing the cell membrane to depolarize and triggering an action potential. TRPM8 receptor agonist-1 can activate signals related to the swallowing reflex and can be used for the research of oropharyngeal dysphagia .
Cat. No.: HY-101229
CAS No.: 140924-23-8
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(2R,3R)-Chlorpheg is a week antagonist of L-homocysteic acid (L-HCA) induced depolarization.(2R,3R)-Chlorpheg also is a weak N-methyl-D-aspartate (NMDA) antagonist .
Cat. No.: HY-107519
CAS No.: 201730-10-1
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(R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations .
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Decamethonium chloride is a depolarizing neuromuscular blocking agent that can be used to study the mechanism of action of muscle relaxants .
Cat. No.: HY-B1700AR
CAS No.: 106861-44-3
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Mivacurium (dichloride) (Standard) is the analytical standard of Mivacurium (dichloride). This product is intended for research and analytical applications. Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell .
Cat. No.: HY-125463
CAS No.: 142021-80-5
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ANQ9040 is a steroidal relaxant. ANQ9040 is a relatively low-affinity and non-depolarizing nicotinic antagonist .
Cat. No.: HY-106330A
CAS No.: 115436-74-3
Synonyms: Win 54177-4 fumarate
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Ipazilide fumarate (Win 54177-4 fumarate) is an antiarrhythmic agent. Ipazilide fumarate reduces K +- depolarized tone. Ipazilide fumarate prolongs ventricular refractoriness and possesses antiectopic activity .
Cat. No.: HY-P1987
CAS No.: 65636-54-6
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Cat. No.: HY-106682
CAS No.: 77862-92-1
Synonyms: AQ-A 39
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Falipamil (AQ-A 39), a calcium channel blocker, is a bradycardic agent. The bradycardic effect results from a reduction in the diastolic depolarization rate and a prolongation of the action potential duration .
Cat. No.: HY-100906
CAS No.: 75667-84-4
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1,1-Dimethyl-4-acetylpiperazinium iodide is an agonist for nicotinic acetylcholine receptor (nAChR) that open ion channels and causes cell membrane depolarization .
Cat. No.: HY-108984
CAS No.: 97120-13-3
Synonyms: 5-(Benzylsulfonyl)-4-bromo-2-methyl-3(2H)-pyridazinone
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BBMP is a permeability transition pore (PTP) inhibitor. BBMP prevents Ca 2+-induced permeability transition and mitochondrial depolarization. BBMP possess potential for the neurodegenerative disorders research .
Cat. No.: HY-N11506
CAS No.: 20931-58-2
Synonyms: St-567 hydrobromide
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Alinidine (St-567) hydrobromide is a specific bradycardic agent. Alinidine hydrobromide reduces the slope of the diastolic depolarization in sinoatrial tissue and Purkinje fibers. Alinidine hydrobromide shows antiischemic and antiarrhythmic effects .
Cat. No.: HY-A0215
CAS No.: 106819-53-8
Synonyms: BW-A 938U; Nuromax
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Doxacurium chloride (BW A938U) is a potent non-depolarizing neuromuscular blocking agent. Doxacurium chloride binds to cholinergic receptors to antagonize acetylcholine, resulting in a block of neuromuscular transmission. Doxacurium chloride can be used for the research of neurological diseases .
Cat. No.: HY-B0517AR
CAS No.: 1722-62-9
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Mepivacaine (hydrochloride) (Standard) is the analytical standard of Mepivacaine (hydrochloride). This product is intended for research and analytical applications. Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
