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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
222 Results for "
depolarization
" in MedChemExpress (MCE) Product Catalog:
Products (222)
222 Results for "depolarization" in MCE Product Catalog:
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6’-Methyl paeonol is a paeonol derivative, which inihibits abnormal depolarizations and reduces the Amyloid β-induced ERK phosphorylation. 6’-Methyl paeonol exhibits alleviating activity against Alzheimer’s Disease .
Cat. No.: HY-B0615A
CAS No.: 29560-58-5
Synonyms: EN 313; Ethmozin; Moracizine
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Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .
Cat. No.: HY-168771
CAS No.: 71822-19-0
Synonyms: γDGG TFA; γ-D-Glutamylglycine TFA
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gamma-DGG TFA is the antagonist for excitatory amino acid, that blocks NMDA-(HY-17551), Kainate-(HY-N2309) and Quisqualate-(HY-12597) induced depolarization, and antagonises the excitatory postsynaptic potential (e.p.s.p.) in rat hippocampal slices .
Cat. No.: HY-B0292
CAS No.: 64228-79-1
Synonyms: BW-33A free acid
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tracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation .
Cat. No.: HY-165327
CAS No.: 120755-15-9
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AGN-190383 is a bee venom phospholipase A2 inhibitor. AGN 190383 inhibits both hormone-operated and depolarization-dependent calcium mobilization as well as fMLP stimulated increases in free cytosolic calcium. AGN-190383 has anti-inflammatory activity .
Cat. No.: HY-172116
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Mitochondria modulator-2 (Compound Ir1) induces the depolarization of mitochondrial membrane potential, induces ROS generation, inhibits cell migration of A549, arrests the cell cycle at G2/M phase, and induces apoptosis in A549 .
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Mepivacaine (Standard) is the analytical standard of Mepivacaine. This product is intended for research and analytical applications. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization .
Cat. No.: HY-158918
CAS No.: 2661108-93-4
Synonyms: 4-CF3-Triphenylphosphonium-DC
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4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .
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Phensuximide (Standard) is the analytical standard of Phensuximide. This product is intended for research and analytical applications. Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal .
Cat. No.: HY-136677
CAS No.: 118549-42-1
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LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.
Cat. No.: HY-14232
CAS No.: 1146395-46-1
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TTA-A8 (Compound 13) is a short-acting T-type calcium channel antagonist with oral activity, exhibiting an IC50 value of 31.3 nM in the FLIPR depolarization assay. TTA-A8 possesses favorable pharmacokinetic properties, making it suitable for research on epilepsy and sleep .
Cat. No.: HY-170559
CAS No.: 3054263-27-0
EGFR-IN-141 (Compound 8I) is the inhibitor for EGFR with an IC50 of 2.67 nM. EGFR-IN-141 exhibits cytotoxicity in cancer cell A549 with an IC50 of 13.75 μM. EGFR-IN-141 induces apoptosis and mitochondrial membrane depolarization, and exhibits potential antitumor efficacy .
Cat. No.: HY-17440R
CAS No.: 119302-91-9
Synonyms: ORG 9426 Bromide (Standard)
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Rocuronium (Bromide) (Standard) is the analytical standard of Rocuronium (Bromide). This product is intended for research and analytical applications. Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation.
Cat. No.: HY-P5868
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Cat. No.: HY-135121R
CAS No.: 57530-40-2
Synonyms: Ethacizin (Standard); NIK-244 (Standard)
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Ethacizine (hydrochloride) (Standard) is the analytical standard of Ethacizine (hydrochloride). This product is intended for research and analytical applications. Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide . Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction .
Cat. No.: HY-B0118AR
CAS No.: 50700-72-6
Synonyms: ORG NC 45 (Standard)
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Vecuronium (bromide) (Standard) is the analytical standard of Vecuronium (bromide). This product is intended for research and analytical applications. Vecuronium (ORG NC 45) bromide is a non-depolarizing neuromuscular blocking agent that also acts as a nicotinic acetylcholine receptor (nAChR) inhibitor, a muscle relaxant, and can be used for pre-surgical anesthesia .
Cat. No.: HY-117055
CAS No.: 103295-92-7
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Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca 2+ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (Vh=-20 mV: IC50=2.3 nM; Vh=-50 mV: IC50=100 nM) .
Cat. No.: HY-103313
CAS No.: 121346-33-6
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SR33805 oxalate is a potent Ca 2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca 2+ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts .
Cat. No.: HY-114920
CAS No.: 40680-87-3
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Piprofurol is a calcium channel inhibitor. Piprofurol inhibits the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta in a concentration-dependent manner and relaxes the K +-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
