Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
49 Results for "
dsDNA
" in MedChemExpress (MCE) Product Catalog:
Products (49)
49 Results for "dsDNA" in MCE Product Catalog:
Cat. No.: HY-D3404
CAS No.: 169454-13-1
Cat. No.: HY-D3414
CAS No.: 169454-17-5
Target:
Research Areas:
BODi-3 is an orange fluorescent dye. As a cell-impermeable nucleic acid stain, BODi-3 exhibits no fluorescence in the absence of nucleic acids, but shows multiple fluorescence enhancement upon binding to dsDNA. BODi-3 can be used for nucleus imaging, bacterial and sperm labeling, nucleic acid detection and amplification, and as a temperature sensor.
Cat. No.: HY-185129
Target:
Research Areas:
Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.
Cat. No.: HY-165400
CAS No.: 143413-84-7
Cat. No.: HY-101879R
CAS No.: 65-61-2
Cat. No.: HY-P992101
CAS No.: 3057276-00-0
Synonyms: AUR-200
Target:
Research Areas:
Cat. No.: HY-114180R
CAS No.: 2262452-06-0
Synonyms: RU320521 (Standard)
Research Areas:
RU.521 (Standard) is the analytical standard of RU.521 (HY-114180). This product is intended for research and analytical applications. RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .
Cat. No.: HY-147129
CAS No.: 2369750-66-1
Target:
Research Areas:
cGAS-IN-9 is a cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) inhibitor, with IC50 values of 27.5 nM and 5.15 μM against human and murine cGAS, respectively. cGAS-IN-9 shows weak inhibitory activity against human soluble adenylate cyclase, with an IC50 of 26.4 μM. cGAS-IN-9 inhibits dsDNA-induced expression of IFNB1 and CXCL10, as well as activation of the NF-κB pathway, in human immune cells. cGAS-IN-9 can be used in research related to cGAS-dependent inflammatory diseases .
Cat. No.: HY-189635
Target:
Research Areas:
NS3-IN-2 is a dual-target inhibitor targeting both NS2B‑NS3pro and NS3hel of West Nile virus (WNV). NS3-IN-2 inhibits the enzymatic activity of NS2B‑NS3pro toward polypeptide substrates in a non-competitive manner; for NS3hel, the compound exhibits a non-competitive inhibition mode with respect to ATP and competitive inhibition with respect to the dsDNA substrate. In biochemical assays, NS3-IN-2 has an IC50 = 4.4 μM against NS2B‑NS3pro and an IC50 = 24.0 μM against NS3hel helicase activity. NS3-IN-2 reduces WNV viral replication and exhibits cytotoxicity in hepatoma cells. NS3-IN-2 can be used for research on West Nile virus infection .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
