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Cat. No.: HY-114180R

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RU.521 (Standard)

Name: RU.521 (Standard)
Brand: MedChemExpress
SKU: HY-114180R
Availability: PreOrder

(Synonyms: RU320521 (Standard))

RU.521 (Standard) is the analytical standard of RU.521 (HY-114180). This product is intended for research and analytical applications. RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

For research use only. We do not sell to patients.

CAS No.: 2262452-06-0
Formula: C₁₉H₁₂Cl₂N₄O₃
Molecular Weight:415.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RU.521 (Standard) Chemical Structure

CAS No.: 2262452-06-0

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2262452-06-0
Molecular Weight 415.23
Formula C₁₉H₁₂Cl₂N₄O₃
SMILES

O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
Synonyms

RU320521 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750. [Content Brief]

[2]. Xu Q, et al. Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice. Life Sci. 2020 Nov 1;260:118315. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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