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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
87 Results for "
5-HT1B/1D
" in MedChemExpress (MCE) Product Catalog:
Products (87)
87 Results for "5-HT1B/1D" in MCE Product Catalog:
Cat. No.: HY-103199
CAS No.: 39731-05-0
Synonyms: SDZ21009
Target:
Research Areas:
Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37) .
Cat. No.: HY-W018475B
CAS No.: 159776-67-7
Synonyms: MK 462 hemisulfate hemihydrate
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Research Areas:
Rizatriptan (MK 462) hemisulfate hemihydrate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan hemisulfate hemihydrate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system .
Cat. No.: HY-117575
CAS No.: 133025-23-7
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Research Areas:
WAY-100135 is a serotonergic compound belonging to the phenylpiperazine family, utilized in scientific research for its role as a strong antagonist of the 5-HT1A receptor and a partial agonist of the 5-HT1D receptor, with minimal activity at the 5-HT1B receptor.
Cat. No.: HY-A0010R
CAS No.: 177834-92-3
Synonyms: Eletriptan HBr (Standard); UK-116044 hydrobromide (Standard)
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Research Areas:
Eletriptan hydrobromide (Standard) is an analytical standard for Eletriptan hydrobromide. This product is intended for research and analytical applications. Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki of 0.92 nM and 3.14 nM, respectively .
Cat. No.: HY-B0206S
CAS No.: 1216984-85-8
Cat. No.: HY-B1658AR
CAS No.: 158930-17-7
Synonyms: (R)-Frovatriptan succinate hydrate (Standard); SB 209509 succinate hydrate (Standard); VML 251 succinate hydrate (Standard)
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Frovatriptan (succinate hydrate) (Standard) is the analytical standard of Frovatriptan (succinate hydrate). This product is intended for research and analytical applications. Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research .
Cat. No.: HY-B1658BS
Synonyms: (R)-Frovatriptan-d3 succinate; SB 209509-d3 succinate; VML 251-d3 succinate
Cat. No.: HY-10847A
CAS No.: 1226917-67-4
Synonyms: SB-277011A dihydrochloride
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Research Areas:
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor antagonist, with pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.
Cat. No.: HY-W022362
CAS No.: 2954-50-9
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Research Areas:
2-Aminotetralin is a potent and selective serotonin 5-HT1 agonist. 2-Aminotetralin exhibits high affinity (Ki≤25 nM) and at least 50-fold stereoselective preference at 5-HT1A, 5-HT1B, and 5-HT1D receptors .
Cat. No.: HY-120688
CAS No.: 177947-03-4
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L-772405 is a selective 5-HT1D receptor agonist with the Ki values of 318, 29 and ＞ 1000 nM aganist guinea pig 5-HT1B receptor, guinea pig 5-HT1D receptor and rat 5-HT rransporter, respectively. L-772405 decreases the potassium-induced outflow of 5-HT with an IC50 value of 240 nM .
Cat. No.: HY-124117
CAS No.: 119193-37-2
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LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a Ki of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors .
Cat. No.: HY-A0039S2
Cat. No.: HY-B0121BS1
CAS No.: 1020764-38-8
Synonyms: GR 43175 free base-d6
Cat. No.: HY-B0121A
CAS No.: 103628-62-2
Synonyms: GR 43175 hydrochloride
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Research Areas:
Sumatriptan hydrochloride (GR 43175) is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan hydrochloride can be used for migraine headache research .
Cat. No.: HY-123704
CAS No.: 1350965-83-1
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Research Areas:
CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT1A , 5-HT1B ,5-HT1C and 5-HT1D with pEC50 values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease .
Cat. No.: HY-B0121BS2
Synonyms: GR 43175 free base-d5
Cat. No.: HY-B0121BS3
Synonyms: GR 43175 free base-d6 formate
Cat. No.: HY-132343S
CAS No.: 1217618-32-0
Cat. No.: HY-108139
CAS No.: 194942-63-7
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F-14258 is a 5-HT1B/1D receptor agonist. F-14258 can achieve receptor specific analgesia through local administration. F-14258 can be used for research on ear pain .
Cat. No.: HY-106157R
CAS No.: 170912-52-4
Synonyms: F-11356 free base (Standard)
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Research Areas:
Donitriptan (Standard) is the analytical standard of Donitriptan (HY-106157). This product is intended for research and analytical applications. Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
