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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
93 Results for "
Cyclic GMP
" in MedChemExpress (MCE) Product Catalog:
Products (93)
93 Results for "Cyclic GMP" in MCE Product Catalog:
Cat. No.: HY-W507009
CAS No.: 40968-45-4
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L-Arginyl-L-alanine is a dipeptide, is a vascular smooth muscle-derived relaxing factor. L-Arginyl-L-alanine increases the smooth muscle levels of cyclic GMP and nitrite in endothelium-denuded arterial rings .
Cat. No.: HY-W654000
Synonyms: Guanosine 3',5'-Cyclic-13C,15N2 monophosphate
Cat. No.: HY-110382S
Synonyms: c-di-GMP-13C20,15N10 disodium; Cyclic diguanylate-13C20,15N10 disodium; 5GP-5GP-13C20,15N10 disodium
Cat. No.: HY-50723S1
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Isotope-Labeled Compounds Endogenous Metabolite Phosphodiesterase (PDE) Caspase Bcl-2 Family Apoptosis
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3-Methylxanthine-d3 is deuterated labeled 3-Methylxanthine (HY-50723). 3-Methylxanthine is a blood-brain barrier-permeable cyclic GMP phosphodiesterase inhibitor, with an IC50 of 920 μM against guinea pig cyclic GMP phosphodiesterase. 3-Methylxanthine relaxes the spontaneous tension of isolated guinea pig tracheal smooth muscle preparations. Through a DRD1-dependent pathway, 3-Methylxanthine upregulates the expression of γH2AX and activated caspase-3, downregulates the expression of Bcl-2, and enhances Cisplatin-induced apoptosis (apoptosis) in ovarian cancer cells both in vitro and in vivo. 3-Methylxanthine induces clonic convulsions in the central nervous system. 3-Methylxanthine is the major metabolite of Theophylline (HY-B0809). 3-Methylxanthine can be used in studies related to ovarian cancer and neurotoxic convulsions .
Cat. No.: HY-P3193
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Cat. No.: HY-172533
3’,5’-DiOA-dC is a hydrophobic nucleotide lipid and a ligand for the STING agonist c-di-GMP (CDG). 3’,5’-DiOA-dC can assemble with CDG and form stable cyclic dinucleotide nanoparticles via various supramolecular forces driven by molecular recognition. 3’,5’-DiOA-dC can decrease tumor weight and volume, increase CD8 T cell, neutrophils as well as NK cell counts in tumor microenvironment in combination with CDG. 3’,5’-DiOA-dC also increases the levels of TNF-α and IFN-γ in murine melanoma model .
Synonyms: Cyclic adenosine monophosphate (GMP); Adenosine Cyclic 3', 5'-monophosphate (GMP); cAMP (GMP)
Cat. No.: HY-123468A
CAS No.: 92564-08-4
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HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .
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Phensuximide (Standard) is the analytical standard of Phensuximide. This product is intended for research and analytical applications. Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal .
Cat. No.: HY-106110
CAS No.: 101758-79-6
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OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .
Cat. No.: HY-171020
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8-Nitro-2'3'cGMP is a cyclic nucleotide derivative. 8-Nitro-2'3'cGMP is composed of 8-Nitro-GMP, ribose and phosphoric acid.
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Terpenoids Diterpenoids Senna siamea (Lamarck) H. S. Irwin & Barneby Plants Compositae Extract Other Families Extract
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Cat. No.: HY-E71644
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3',5'-Cyclic-GMP phosphodiesterase (EC 3.1.4.35) belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds.
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Ribonuclease T1 (animal free) (Rnase T1 (animal free)) (EC 4.6.1.24) is an endonuclease that specifically degrades single-stranded RNA. Ribonuclease T1 forms a nucleoside 2′, 3′-cyclic phosphate intermediate to cleave the phosphodiester bond between the 3′-guanosine residue and the 5′-OH group of the adjacent nucleoside to produce a 3′-GMP-terminated oligonucleotide. This product does not contain ingredients of animal origin .
Cat. No.: HY-131764
CAS No.: 58329-72-9
Synonyms: 2′-O-Monobutyryl-cGMP sodium
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2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium is a cyclic GMP-specific phosphodiesterase inhibitor with an I50 value of 35 µM. 2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium inhibits Ca 2+ dependent phosphodiesterase hydrolysis using cAMP or cGMP as substrate .
Cat. No.: HY-129670
CAS No.: 81996-46-5
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KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC). KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K + channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study .
Cat. No.: HY-135110A
CAS No.: 150418-07-8
Synonyms: Rp-8-bromo-Cyclic GMPS
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Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca 2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca 2+ reduction by activating Ca 2+-ATPase and subsequently removing Ca 2+ from the cell .
Cat. No.: HY-P10672
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Cat. No.: HY-100564AR
CAS No.: 2734858-36-5
Synonyms: 2'-3'-Cyclic GMP-AMP sodium (Standard)
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Cat. No.: HY-100564R
CAS No.: 1441190-66-4
Synonyms: 2'-3'-Cyclic GMP-AMP (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
