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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
SGLT
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "SGLT" in MCE Product Catalog:
Cat. No.: HY-14894R
CAS No.: 761423-87-4
Synonyms: ASP1941 (Standard)
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Ipragliflozin (Standard) is the analytical standard of Ipragliflozin. This product is intended for research and analytical applications. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
Cat. No.: HY-14894S2
CAS No.: 2743031-48-1
Synonyms: ASP1941-13C6
Cat. No.: HY-15409S1
Synonyms: BI 10773-13C6
Cat. No.: HY-15409S2
Synonyms: BI 10773-d6
Cat. No.: HY-122473
CAS No.: 1181681-43-5
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fluoro-Dapagliflozin, a structural analog of Dapagliflozin, is a selective SGLT2 inhibitor with Ki values of 5.3 nM and 330 nM for SGLT2 and SGLT1, respectively. fluoro-Dapagliflozin blocks glucose transport and glucose-coupled currents .
Cat. No.: HY-109092A
CAS No.: 2730989-98-5
Synonyms: rel-LIK066
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rel-Licogliflozin is a relative configuration of Licogliflozin (HY-109092). Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor .
Cat. No.: HY-15461S
CAS No.: 1298086-22-2
Synonyms: PF-04971729-d5
Cat. No.: HY-15461S1
Synonyms: PF-04971729-d9
Cat. No.: HY-125594
CAS No.: 209746-56-5
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T-1095A is an active metabolite of T-1095 (HY-106158) (an SGLT inhibitor) .
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HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities .
Cat. No.: HY-124664
CAS No.: 957772-01-9
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TP0438836 (compound 30b) is a SGLT1 inhibitor, with IC50 values of 28 nM and 7 nM for hSGLT1 and hSGLT2, respectively. TP0438836 can be used in diabetes research .
Cat. No.: HY-125327
CAS No.: 1610007-47-0
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YM-543 is a selective SGLT2 inhibitor that effectively reduces hyperglycemia in type 2 diabetic mice through increased urinary glucose excretion. YM-543 demonstrates potent inhibition of both mouse and human SGLT2 activities at nanomolar concentrations. YM-543, when administered orally, significantly improves glucose tolerance in diabetic models and sustains its effects for over 12 hours. YM-543, in combination with other antidiabetic agents like rosiglitazone or metformin, enhances the therapeutic effects on diabetic symptoms. YM-543 does not affect blood glucose levels in normal mice, indicating its specificity for diabetic conditions.
Cat. No.: HY-10451S2
Synonyms: JNJ 28431754-d6
Synonyms: BMS-801576
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Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2, that can be used to improve glycemic control and attenuate type 2 diabetes .
Cat. No.: HY-10450S5
Cat. No.: HY-10450S2
CAS No.: 1224234-25-6
Synonyms: BMS-512148-d4
Cat. No.: HY-10450S3
Synonyms: BMS-512148-13C6
Cat. No.: HY-114598
CAS No.: 152595-59-0
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WAY-123783 is a potent, selective and orally active sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor producing activity after metabolism. WAY-123783 can increase the excretion of sugar in urine and at the same time lower the blood sugar level in db/db mice (ED50 = 9.85 mg/kg). WAY-123783 can be used for the research of metabolic disease, such as diabetes .
Cat. No.: HY-180201
CAS No.: 1061314-92-8
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SGLT2-IN-4 (Compound 1) is a selective and orally active sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor. SGLT2-IN-4 can increase the proportion of protein α-helix and enhance the stability of the SGLT2-D201A mutant. SGLT2-IN-4 can be used for the research of type 2 diabetes .
Cat. No.: HY-180527
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SGLT2-IN-5 (Compound 99) is an orally active SGLT2 inhibitor with IC₅₀ values for SGLT2, SGLT1, and DPP4 of 0.8, 23, and 58 nM respectively. SGLT2-IN-5 controls blood sugar levels in diabetic rat models and increases the levels of active GLP-1. SGLT2-IN-5 can be used for the study of type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
