T-1095A
T-1095A is an active metabolite of T-1095 (HY-106158) (an SGLT inhibitor).
For research use only. We do not sell to patients.
- CAS No.: 209746-56-5
- Formula: C24H26O9
- Molecular Weight:458.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
211 nM
Compound: 2, T-1095A
|
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | EC50 |
6.6 nM
Compound: 2, T-1095A
|
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]AMG accumulation
|
[PMID: 18260618] |
| CHO | IC50 |
240 nM
Compound: 1, T1095A
|
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting
|
[PMID: 20690635] |
| CHO | IC50 |
5.2 nM
Compound: 1, T1095A
|
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scintillation counting
|
[PMID: 20690635] |
| CHO-K1 | IC50 |
0.011 μM
Compound: 1
|
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells
Inhibitory activity towards human SGLT2 expressed in CHO-K1 cells
|
[PMID: 16198559] |
| CHO-K1 | IC50 |
0.139 μM
Compound: 1
|
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells
Inhibitory activity towards human SGLT1 expressed in CHO-K1 cells
|
[PMID: 16198559] |
| CHO-K1 | IC50 |
0.011 μM
Compound: 1
|
Inhibitory activity against SGLT2 expressed in CHO-K1 cells
Inhibitory activity against SGLT2 expressed in CHO-K1 cells
|
[PMID: 16380256] |
| CHO-K1 | IC50 |
0.139 μM
Compound: 1
|
Inhibitory activity against SGLT1 expressed in CHO-K1 cells
Inhibitory activity against SGLT1 expressed in CHO-K1 cells
|
[PMID: 16380256] |
| L6 | IC50 |
>10000 nM
Compound: 1, T1095A
|
Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting
Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation counting
|
[PMID: 20690635] |
Chemical Information
-
CAS No. 209746-56-5
-
Molecular Weight 458.46
-
Formula C24H26O9
-
SMILES
O=C(C1=C(O)C=C(C)C=C1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CCC3=CC=C4OC=CC4=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)