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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
VDR
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "VDR" in MCE Product Catalog:
Cat. No.: HY-161778
CAS No.: 3049802-32-3
Research Areas:
ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization .
Cat. No.: HY-179431
Target:
Research Areas:
VDR ligand-1 (compound 13a) is a nonsecosteroidal VDR agonist with an EC50 value of 16 nM. VDR ligand-1 can be used for osteoporosis, psoriasis, and cancer research .
Cat. No.: HY-169264
Target:
Research Areas:
SJYHJ-026 is a PROTAC degrader targeting PXR, with a DC50 of 86.6 nM in SNU-C4 HiBiT-PXR KI cells. SJYHJ-026 shows higher selectivity for PXR over CAR, VDR, FXR, LXRα and LXRβ, and can bind to VHL to form a PXR-SJYHJ-026-VHL complex, inducing proteasomal degradation of PXR. SJYHJ-026 blocks agonist-induced PXR-mediated gene expression (including CYP3A4) and reduces basal PXR activity at the CYP3A4 promoter. SJYHJ-026 can be used for the research of colorectal cancer .
Cat. No.: HY-169279
Target:
Research Areas:
PROTAC PXR degrader-1 is a PROTAC degrader targeting PXR, with a DC50 value of 49.8 nM in SNU-C4 3xFLAG-PXR KI cells. PROTAC PXR degrader-1 exhibits selectivity towards CAR, VDR, FXR, LXRα and LXRβ. PROTAC PXR degrader-1 induces the formation of a ternary complex with PXR and VHL, triggering proteasomal degradation of PXR. PROTAC PXR degrader-1 reduces both agonist-induced and basal PXR-mediated CYP3A4 promoter activation, and decreases the expression of endogenous CYP3A4 gene in cancer cells. PROTAC PXR degrader-1 enhances the cytotoxic effect of paclitaxel on cancer cells. PROTAC PXR degrader-1 can be used for the research of colorectal cancer .
Cat. No.: HY-P73542
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VDR; Vitamin D Receptor; NR1I1; Nuclear Receptor Subfamily 1 Group I Member 1; 1,25-Dihydroxyvitamin D3 Receptor; Vitamin D3 Receptor; PPP1R163; Vitamin D (1,25-Dihydroxyvitamin D3) Receptor; Protein Phosphatase 1, Regulatory Subunit 163; 1,25-Dihydroxyvi
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-N10508S
CAS No.: 1637678-42-2
Cat. No.: HY-118970
CAS No.: 233268-78-5
Target:
Research Areas:
LG190155 is a nonsteroidal vitamin D receptor (VDR) agonist. LG190155 activates VDR in mesenchymal stem cells, thereby upregulating the BMP6-IL6 autocrine axis. Pretreatment of mesenchymal stem cells with LG190155 significantly enhances their ability to induce differentiation of acute myeloid leukemia cells, without inducing hypercalcemia. LG190155 is applicable to research related to acute myeloid leukemia (AML) .
Cat. No.: HY-15364
CAS No.: 130447-37-9
Target:
Research Areas:
19-nor-1α,25-Dihydroxyvitamin D3 is a vitamin D receptor (VDR) agonist with an EC50 of 4.8 nM. 19-nor-1α,25-Dihydroxyvitamin D3 binds to VDR and promotes gene transcription. 19-nor-1α,25-Dihydroxyvitamin D3 can be used in the research of diseases related to the vitamin D signaling pathway .
Cat. No.: HY-RS16287
Target:
Research Areas:
Cyp27b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cyp27b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-10002S2
CAS No.: 1539301-39-7
Synonyms: 1,25-Dihydroxyvitamin D3-d9
Cat. No.: HY-166525S
Synonyms: PRI 2202-d4; Impurity D of Calcipotriol-d4
Cat. No.: HY-P86960
Synonyms: Activator-recruited cofactor 36 kDa component antibody; ARC36 antibody; DRIP36 antibody; FLJ10956 antibody; HSPC126 antibody; med4 antibody; MED4_HUMAN antibody; Mediator complex subunit 4 antibody; Mediator of RNA polymerase II transcription subunit 4 antibody; Mediator of RNA polymerase II transcription, subunit 4 homolog antibody; Activator-recruited cofactor 36 kDa component antibody; ARC36 antibody; DRIP36 antibody; FLJ10956 antibody; HSPC126 antibody; med4 antibody; MED4_HUMAN antibody; Mediator complex subunit 4 antibody; Mediator of RNA polymerase II transcription subunit 4 antibody; Mediator of RNA polymerase II transcription, subunit 4 homolog antibody; OTTHUMP00000018390 antibody; OTTHUMP00000018391 antibody; OTTHUMP00000018392 antibody; RP11-90M2.2 antibody; TRAP/SMCC/PC2 subunit p36 subunit antibody; TRAP36 antibody; VDR; IP : antibody; Vitamin D3 receptor-interacting protein complex 36 kDa component antibody;
Cat. No.: HY-32351S3
CAS No.: 1539301-45-5
Synonyms: 25-hydroxy Vitamin D3-d9
Cat. No.: HY-131492S
Cat. No.: HY-10002AR
CAS No.: 61476-45-7
Synonyms: 1α,25-Dihydroxy-3-epi-vitamin-D3 (Standard)
Target:
Research Areas:
(1S)-Calcitriol (Standard) is the analytical standard of (1S)-Calcitriol (HY-10002A). This product is intended for research and analytical applications. (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .
Cat. No.: HY-182038
Target:
Research Areas:
TGF-β1/Smad3-IN-2 is an orally active antifibrotic agent. TGF-β1/Smad3-IN-2 has high affinity for VDR and can inhibit the TGFβ/SMAD3 signaling pathway. TGF-β1/Smad3-IN-2 inhibits hepatic stellate cell activation, reduces extracellular matrix deposition, and alleviates liver fibrosis in a bile duct ligation mouse model. TGF-β1/Smad3-IN-2 can be used for the research of liver fibrosis .
Cat. No.: HY-10002AS
CAS No.: 1539301-06-8
Synonyms: 1α,25-Dihydroxy-3-epi-vitamin D3-d3
Cat. No.: HY-10002AS2
CAS No.: 1202355-83-6
Synonyms: 1α,25-Dihydroxy-3-epi-vitamin D3-d6
Cat. No.: HY-180503
CAS No.: 284041-36-7
Target:
Research Areas:
19-Nor-22-oxa-1a,25(OH)2-VD3 is a vitamin D₃ analogue. 19-Nor-22-oxa-1a,25(OH)2-VD3 has an extremely low affinity for the vitamin D receptor (VDR) and hardly binds to the vitamin D binding protein (DBP). 19-Nor-22-oxa-1a,25(OH)2-VD3 can effectively induce the differentiation of HL-60 cells and cause G₀-G₁ phase cell cycle arrest. 19-Nor-22-oxa-1a,25(OH)2-VD3 can be used to study diseases such as excessive hyperparathyroidism .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
