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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
78 Results for "
PDK1
" in MedChemExpress (MCE) Product Catalog:
Products (78)
78 Results for "PDK1" in MCE Product Catalog:
Cat. No.: HY-P706083
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PDK1; Mitochondrial Pyruvate Dehydrogenase, Lipoamide, Kinase Isoenzyme 1; Pyruvate Dehydrogenase Kinase 1; Pyruvate Dehydrogenase Kinase, Isozyme 1; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 1, Mitochondrial; Pyruvate Dehydrogenase Kinase Isoform 1; Pyruvate Dehydrogenase Kinase, Isoenzyme 1; Protein-Serine/Threonine Kinase; PDH Kinase 1; PDHK1; Pyruvate Dehydrogenase (Acetyl-Transferring) Kinase Isozyme 1, Mitochondrial
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-11005R
CAS No.: 702674-56-4
Target:
Research Areas:
BX-912 (Standard) is the analytical standard of BX-912 (HY-11005). This product is intended for research and analytical applications. BX-912 is a direct, selective, and ATP-competitive PDK1 inhibitor (IC50=26 nM). BX-912 blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induces apoptosis [1].
Cat. No.: HY-RS17027
Target:
Research Areas:
Pdpk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdpk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P705581
Synonyms: PDK1; Mitochondrial Pyruvate Dehydrogenase, Lipoamide, Kinase Isoenzyme 1; Pyruvate Dehydrogenase Kinase 1; Pyruvate Dehydrogenase Kinase, Isozyme 1; [Pyruvate Dehydrogenase (Acetyl-Transferring)] Kinase Isozyme 1, Mitochondrial; Pyruvate Dehydrogenase Ki
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-RS10287
Target:
Research Areas:
PDPK1 Human Pre-designed siRNA Set A contains three designed siRNAs for PDPK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W074538
CAS No.: 96799-02-9
Synonyms: 5-(Furan-2-yl)-1H-pyrazol-3-amine
3-Amino-5-(2-furyl)pyrazole (Compound 14) is a PDK1 binder with an IC50 of 313 μM. 3-Amino-5-(2-furyl)pyrazole can be used in cancer research [1].
Cat. No.: HY-119134
CAS No.: 253440-95-8
PX-316 is an Akt inhibitor. PX-316 can phosphorylate Akt, but does not inhibit the phosphorylation of PDK1 or PKC. PX-316 uniquely increases the expression of a group of mitochondrial-related genes. PX-316 can be used for the study of colon cancer and breast cancer [1].
Cat. No.: HY-N17990
CAS No.: 114882-17-6
Target:
Cat. No.: HY-10514R
CAS No.: 702675-74-9
Target:
Research Areas:
BX795 (Standard) is the analytical standard of BX795 (HY-10514). This product is intended for research and analytical applications. BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM. BX795 is also a potent and relatively specific inhibitor of TBK1 and IKKε, with an IC50 of 6 and 41 nM, respectively. BX795 blocks phosphorylation of S6K1, Akt, PKCδ, and GSK3β, and has lower selectivity over PKA, PKC, c-Kit, GSK3β etc. BX795 modulates autophagy [1] .
Cat. No.: HY-P701738
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDPK1; PkB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PkB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-N20662
CAS No.: 2779545-15-0
Cat. No.: HY-P701739
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDPK1; PkB Kinase Like Gene 1; 3-Phosphoinositide Dependent Protein Kinase 1; PkB Kinase; PDK1; PRO0461; 3-Phosphoinositide-Dependent Protein Kinase 1; HPDK1; Non-Specific Serine/Threonine Protein Kinase
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-181670
Research Areas:
WH23 is a dehydrogenase/reductase SDR family member 11 (DHRS11) inhibitor with IC50 values of 0.037 μM. WH23 binds to DHRS11, forming a hydrogen bond with the enzyme’s His210 residue. WH23 suppresses androgen receptor mRNA and protein expression, reduces c-Myc expression, and inhibits cancer cell proliferation. WH23 inhibits PI3K/AKT signaling by reducing phosphorylation of PDK1, AKT, mTOR, and ERK. WH23 enhances Capivasertib (HY-15431)-induced cytotoxicity and apoptosis. WH23 can be used for the research of luminal androgen receptor-positive triple-negative breast cancer [1].
Cat. No.: HY-L015
1,149 compounds
The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.
MCE owns a unique collection of 1,149 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.
Cat. No.: HY-N2942
CAS No.: 52328-96-8
Cat. No.: HY-183583
CAS No.: 2709068-47-1
Target:
Research Areas:
HIF-2α-IN-18 is a selective HIF-2α inhibitor with a human IC50 of 8.1 nM. HIF-2α-IN-18 binds to the HIF-2α PAS-B domain, induces conformational perturbations at the HIF-2α/ARNT dimerization interface, destabilizes the HIF-2α/ARNT heterodimer, and blocks HIF-2α-mediated transcriptional activity. HIF-2α-IN-18 inhibits hypoxia-induced expression of HIF-2α target genes EPO and SERPINE1, without inhibiting HIF-1α target genes PGK1 and PDK1. HIF-2α-IN-18 can be used for the research of clear cell renal cell carcinoma, hepatocellular carcinoma[1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
