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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1330 Results for "
monomeric native state
" in MedChemExpress (MCE) Product Catalog:
Products (1330)
1330 Results for "monomeric native state" in MCE Product Catalog:
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RBN013209 is an orally active small molecule inhibitor of CD38 with an IC50 of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD + to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors .
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Cat. No.: HY-P2541A
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Cat. No.: HY-N8028
CAS No.: 83048-35-5
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Eucommia ulmoides Oliver Flavonols Flavonoids Phenols Polyphenols Plants Disease Research Fields Eucommiaceae Extract Cancer
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SB399885 is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with pKi values 9.11 and 9.02 for human recombinant and native 5-HT6 receptors, respectively. SB399885 has cognitive enhancing properties .
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Nelivaptan (SSR-149415) is a selective and orally active vasopressin V1b receptor antagonist (Ki: 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Nelivaptan inhibits arginine vasopressin (AVP)-induced Ca 2+ increase and corticotropin secretion. Nelivaptan can be used for research of stress, anxiety and depression .
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Microorganisms Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-W009749
CAS No.: 56-88-2
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Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields
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Cat. No.: HY-W009749C
CAS No.: 61125-50-6
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Cat. No.: HY-K1103
MCE Coomassie Blue Fast Staining Solution (No Heating, 10×) uses Coomassie Brilliant Blue G250 as the dye. It can be used for rapid, sensitive staining of protein gels in SDS-PAGE or Native-PAGE without contamination, or for detecting residual proteins on PAGE gels after Western Blot transfer. The 25 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.
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Cat. No.: HY-160406
CAS No.: 2332803-84-4
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SNX281 is a selective STING agonist, with IC50 values of 4.1, 4.5, 10.7, and 3.7 μM against human, mouse, rat, and monkey STING, respectively. SNX281 undergoes homodimerization at the STING binding site, triggering a conformational shift of STING from an inactive open state to an active closed state, thereby driving downstream STING-dependent signaling pathways. SNX281 induces type I interferons, IFN-β, TNF-α, IL-6, cytokine release, T cell responses, and long-lasting immune memory. SNX281 exhibits anti-tumor activity and is applicable to research related to colorectal cancer, melanoma, advanced solid tumors, lymphoma, and ovarian cancer .
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Synonyms: Dichlorophenylindophenol sodium; DCPIP sodium; Indochlorophenol sodium
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RBC8 is a selective and allosteric RALA and RALB inhibitor. RBC8 stabilizes the inactive GDP-bound state of Ral, preventing its activation. RBC8 promotes the phosphorylation of proteins related to the MAPK/JNK pathway. RBC8 has the activity of inhibiting tumor cell proliferation, migration and invasion. RBC8 is used in the study of various cancers such as lung cancer, gastric cancer, and multiple myeloma .
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Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Cornaceae Extract
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Cat. No.: HY-P1045
CAS No.: 380488-27-7
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BRD9876 is the “rigor” inhibitor that locks kinesin-5 (Eg5) in a state with enhanced microtubules (MTs) binding, leading to bundling and stabilization of MTs. BRD9876 interacts with the tyrosine 104 residue that is part of the α4-α6 allosteric binding pocket. BRD9876 specifically targets microtubule-bound Eg5 and selectively inhibits myeloma over CD34 cells. BRD9876 has the potential for multiple myeloma (MM) research .
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Cat. No.: HY-W250727
CAS No.: 53313-85-2
Synonyms: 6-(p-Tolylamino)naphthalene-2-sulfonate sodium
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
