1. Neuronal Signaling
    Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. Calcium Channel
    Endogenous Metabolite
  3. 1-Octanol

1-Octanol (Synonyms: Octanol)

Cat. No.: HY-W032013 Purity: >98.0%
Handling Instructions

1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents. 1-Octanol is a highly attractive biofuel with diesel-like properties.

For research use only. We do not sell to patients.

1-Octanol Chemical Structure

1-Octanol Chemical Structure

CAS No. : 111-87-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 172 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents[1]. 1-Octanol is a highly attractive biofuel with diesel-like properties[2].

IC50 & Target

T-type calcium channel

4 μM (IC50)

Human Endogenous Metabolite

 

In Vitro

1-octanol inhibits native T-currents at subanesthetic concentrations with an IC50 of approximately 4 μM. In contrast, 1-octanol is up to 30-fold less potent in inhibiting recombinant CaV3.3 T-channels heterologously expressed in human embryonic kidney cells[1].

Molecular Weight

130.23

Formula

C₈H₁₈O

CAS No.

111-87-5

SMILES

OCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1919.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6787 mL 38.3936 mL 76.7872 mL
5 mM 1.5357 mL 7.6787 mL 15.3574 mL
10 mM 0.7679 mL 3.8394 mL 7.6787 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (17.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (17.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (17.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

1-OctanolOctanolCalcium ChannelEndogenous MetaboliteCa2+ channelsCa channelssaturatedfattyalcoholT-channelsT-currentsbiofueldiesel-likeInhibitorinhibitorinhibit

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Product name:
1-Octanol
Cat. No.:
HY-W032013
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