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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
100 Results for "
AR PROTAC
" in MedChemExpress (MCE) Product Catalog:
Products (100)
100 Results for "AR PROTAC" in MCE Product Catalog:
Cat. No.: HY-175790
CAS No.: 2493425-86-6
Research Areas:
AR/BET ligand-1 is a AR/BET ligand, which can be used for the synthesis of PROTACs, such as PROTAC AR/BET protein degrader-1 (HY-160262) .
Cat. No.: HY-150878
CAS No.: 2632308-13-3
Research Areas:
AR ligand-4 is an androgen receptor (AR) ligand, which can be used for the synthesis of PROTACs, such as ARD-1676 (HY-156111) .
Cat. No.: HY-184957
CAS No.: 3033660-79-3
Research Areas:
Androgen receptor antagonist 15 is an Androgen receptor (AR) antagonist. Androgen receptor antagonist 15 serves as a Ligand for Target Protein for PROTAC for PROTAC AR degraders, such as ARD-61 (HY-139659). Androgen receptor antagonist 15 is applicable to the research of prostate cancer .
Cat. No.: HY-175906
Research Areas:
AR ligand-45 is an androgen receptor (AR) ligand, which can be used for the synthesis of PROTACs, such as SJH1-62B (HY-162241) .
Cat. No.: HY-175939
CAS No.: 2460022-50-6
Research Areas:
AR-V7 ligand-1 is a AR-V7 ligand and can be used for the synthesis of PROTACs, such as MTX-23 (HY-148771) .
Cat. No.: HY-175937
CAS No.: 2682256-03-5
Research Areas:
AR ligand-46 is an androgen receptor (AR) ligand that can be used in studies related to PROTAC synthesis, such as serving as a target protein ligand for A031 (HY-148777) .
Cat. No.: HY-185003
CAS No.: 1571081-31-6
Research Areas:
α1A-AR ligand-1 (Compound 3) is an α1A-AR ligand that can be used to synthesize PROTACs, such as α1A-AR Degrader 9c (HY-147100) .
Cat. No.: HY-171808
CAS No.: 2798907-16-9
Target:
Research Areas:
ITRI-90 is an orally effective androgen receptor (AR) PROTAC degrader. ITRI-90 effectively degrades full-length AR (AR-FL) and its splice variant AR-V7 proteins via the ubiquitin-proteasome system, thereby inhibiting AR transcriptional activity and the expression of its target genes, and further inducing tumor cell apoptosis. ITRI-90 can be used in research related to castration-resistant prostate cancer and Enzalutamide (HY-70002)-resistant prostate cancer .
Cat. No.: HY-175791
CAS No.: 2703756-19-6
Research Areas:
Ethyl-Cha-thalidomide-NH2 is a conjugate of an E3 ligase and a linker, which can be used for the synthesis of PROTACs, such as PROTAC AR/BET protein degrader-1 (HY-160262) .
Cat. No.: HY-139444
CAS No.: 2616553-29-6
Research Areas:
AR ligand-51 is an androgen receptor ligand, which can be used for the synthesis of PROTACs, such as ARD-2585 (HY-139436) .
Cat. No.: HY-168296
CAS No.: 88378-55-6
Research Areas:
AR ligand-29 is the target protein ligand of PROTAC VinclozolinM2-2204 (HY-161741), which can be used for cancer research .
Cat. No.: HY-138641R
CAS No.: 2222112-77-6
Synonyms: ARV-110 (StandARd)
Research Areas:
Bavdegalutamide (Standard) is the analytical standard of Bavdegalutamide (HY-138641). This product is intended for research and analytical applications. Bavdegalutamide (ARV-110) is an orally active, specific androgen receptor (AR) PROTAC degrader. Bavdegalutamide promotes ubiquitination and degradation of AR. Bavdegalutamide can be used for the research of prostate cancer (Pink: AR ligand (HY-168299); Blue: E3 ligase ligand (HY-W093272); Black: linker (HY-W091986)) .
Cat. No.: HY-158101R
CAS No.: 2446928-30-7
Synonyms: CC-94676 (StandARd)
Research Areas:
BMS-986365 (Standard) is the analytical standard of BMS-986365 (HY-158101). This product is intended for research and analytical applications. BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC50 of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC) .
Cat. No.: HY-170305
Research Areas:
E3 Ligase Ligand-linker Conjugate 145 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of PROTAC AR Degrader-7 (HY-160221) .
Cat. No.: HY-182331
CAS No.: 3059574-58-9
WCF-598 is a RXRγ (Kd: 234.2 nM) PROTAC degrader. WCF-598 induces RXRγ degradation via the ubiquitin-proteasome pathway and binds directly to RXRγ. WCF-598 indirectly induces AR-V7 degradation, impairs the stability of the RXRγ-AR-V7 complex, downregulates AR-V7 levels, and inhibits the transcription of downstream target genes of AR-V7. WCF-598 induces tumor cell apoptosis, inhibits cell proliferation, activates the p53 signaling pathway, and suppresses cell cycle progression. WCF-598 can be used for the research of prostate cancer .
Cat. No.: HY-111846R
CAS No.: 1351169-29-3
Research Areas:
PROTAC ERα Degrader-2 (Standard) is the analytical standard of PROTAC ERα Degrader-2 (HY-111846). This product is intended for research and analytical applications. PROTAC ERα Degrader-2 (Compound 11) is a ERα PROTAC degrader. PROTAC ERα Degrader-2 significantly down-regulates the level of ERα in MCF-7 cells.(Pink: AR ligand (HY-43962), Blue: IAP Ligand (HY-177389), Black: Linker (HY-128833)) .
Cat. No.: HY-169976
CAS No.: 2753651-22-6
Research Areas:
E3 Ligase Ligand-linker Conjugate 140 (intermediate I-11) is an E3 ubiquitinase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 140 can be used to synthesize PROTAC AR Degrader-6 (HY-156751) .
Cat. No.: HY-W957364
CAS No.: 2940940-74-7
Research Areas:
Pomalidomide-C2-Br is an E3 Ligase Ligand (HY-14658) and linker (HY-W007731) conjugate. Pomalidomide-C2-Br can be used to synthesize PROTAC AR Degrader-8 (HY-170329) .
Cat. No.: HY-100972R
CAS No.: 1949837-12-0
Target:
Reference Standards PROTACs Epigenetic Reader Domain Apoptosis Ferroptosis c-Myc Androgen Receptor
Research Areas:
ARV-771 (Standard) is the analytical standard of ARV-771 (HY-100972). This product is intended for research and analytical applications. ARV-771 is a BET PROTAC degrader, with Kd values of 34, 4.7, 8.3, 7.6, 9.6 and 7.6 nM against BRD2 (1), BRD2 (2), BRD3 (1), BRD3 (2), BRD4 (1) and BRD4 (2) , respectively. ARV-771 inhibits the transcription of AR/AR-v7 and its downstream target genes. By degrading BRD4 protein, ARV-771 enhances the sensitivity of prostate cancer cells to ferroptosis, suppresses cancer cell viability, and induces apoptosis. ARV-771 downregulates the levels of BRD4, c-MYC and AR-V7 in tumor tissues and inhibits tumor tissue growth. ARV-771 can be used in prostate cancer-related research .
Cat. No.: HY-145388R
CAS No.: 2380274-50-8
Research Areas:
AU-15330 (Standard) is the analytical standard of AU-15330 (HY-145388). This product is intended for research and analytical applications. AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
