AR ligand-51
AR ligand-51 is an androgen receptor ligand, which can be used for the synthesis of PROTACs, such as ARD-2585 (HY-139436).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 97.11%
- CAS. Nr.: 2616553-29-6
- Formel: C14H18ClN3
- Molecular Weight:263.77
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 2616553-29-6
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Appearance Solid
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Molecular Weight 263.77
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Formel C14H18ClN3
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Color White to off-white
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SMILES
N#CC1=CC=C(N([C@H]2CC[C@H](N)CC2)C)C=C1Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 100 mg/mL (379.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.7912 mL | 18.9559 mL | 37.9118 mL | 94.7795 mL |
| 5 mM | 0.7582 mL | 3.7912 mL | 7.5824 mL | 18.9559 mL | |
| 10 mM | 0.3791 mL | 1.8956 mL | 3.7912 mL | 9.4780 mL | |
| 15 mM | 0.2527 mL | 1.2637 mL | 2.5275 mL | 6.3186 mL | |
| 20 mM | 0.1896 mL | 0.9478 mL | 1.8956 mL | 4.7390 mL | |
| 25 mM | 0.1516 mL | 0.7582 mL | 1.5165 mL | 3.7912 mL | |
| 30 mM | 0.1264 mL | 0.6319 mL | 1.2637 mL | 3.1593 mL | |
| 40 mM | 0.0948 mL | 0.4739 mL | 0.9478 mL | 2.3695 mL | |
| 50 mM | 0.0758 mL | 0.3791 mL | 0.7582 mL | 1.8956 mL | |
| 60 mM | 0.0632 mL | 0.3159 mL | 0.6319 mL | 1.5797 mL | |
| 80 mM | 0.0474 mL | 0.2369 mL | 0.4739 mL | 1.1847 mL | |
| 100 mM | 0.0379 mL | 0.1896 mL | 0.3791 mL | 0.9478 mL |
AR ligand-51 Related Classifications
HY-139444 Related Classifications
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