1. PROTAC
    Others
  2. PROTACs
    Androgen Receptor
  3. ARD-2585

ARD-2585 

Cat. No.: HY-139436
Handling Instructions

ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor.

For research use only. We do not sell to patients.

ARD-2585 Chemical Structure

ARD-2585 Chemical Structure

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Description

ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1].

In Vitro

ARD-2585 achieves DC50 values of 0.04-0.1 nM in the VCaP cell line with AR gene amplification and in the LNCaP cell line carrying an AR mutation[1].
ARD-2585 (100 nM) is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% (p < 0.01) and 60% at the 6 h time-point (p > 0.05)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

763.28

Formula

C₄₁H₄₃ClN₈O₅

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
ARD-2585
Cat. No.:
HY-139436
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